Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis

Thierry Gustot, Javier Fernandez, Elisabet Garcia, Filippo Morando, Paolo Caraceni, Carlo Alessandria, Wim Laleman, Jonel Trebicka, Laure Elkrief, Corinna Hopf, Pablo Solís‐Munoz, Faouzi Saliba, Stefan Zeuzem, Augustin Albillos, Daniel Benten, José Luis Montero‐Alvarez, Maria Teresa Chivas, Mar Concepción, Juan Córdoba, Aiden McCormick, Rudolf Stauber, Wolfgang Vogel, Andrea de Gottardi, Tania M.

Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication

Katharina Esser‐Nobis, Christian Harak, Philipp Schult, Yuri Kusov, Volker Lohmann – 11 April 2015 – Hepatitis A virus (HAV) and hepatitis C virus (HCV) are two positive‐strand RNA viruses sharing a similar biology, but causing opposing infection outcomes, with HAV always being cleared and HCV establishing persistence in the majority of infections. To gain deeper insight into determinants of replication, persistence, and treatment, we established a homogenous cell‐culture model allowing a thorough comparison of RNA replication of both viruses.

Racial and ethnic disparities in access to and utilization of living donor liver transplants

Yael R. Nobel, Kimberly A. Forde, Linda Wood, Katarzyna Cartiera, Armando S. Munoz‐Abraham, Peter S. Yoo, Peter L. Abt, David S. Goldberg – 11 April 2015 – Living donor liver transplantation (LDLT) is a comparable alternative to deceased donor liver transplantation and can mitigate the risk of dying while waiting for transplant. Although evidence exists of decreased utilization of living donor kidney transplants among racial minorities, little is known about access to LDLT among racial/ethnic minorities.

First experience of liver transplantation with type 2 donation after cardiac death in France

Eric Savier, Federica Dondero, Eric Vibert, Daniel Eyraud, Hélène Brisson, Bruno Riou, Fabienne Fieux, Salima Naili‐Kortaia, Denis Castaing, Jean‐Jacques Rouby, Olivier Langeron, Safi Dokmak, Laurent Hannoun, Jean‐Christophe Vaillant, the Donation After Cardiac Death Study Group – 10 April 2015 – Organ donation after unexpected cardiac death [type 2 donation after cardiac death (DCD)] is currently authorized in France and has been since 2006. Following the Spanish experience, a national protocol was established to perform liver transplantation (LT) with type 2 DCD donors.

Liver transplantation in patients with end‐stage liver disease requiring intensive care unit admission and intubation

Jan Knaak, Mark McVey, Fateh Bazerbachi, Nicolás Goldaracena, Vinzent Spetzler, Nazia Selzner, Mark Cattral, Paul Greig, Les Lilly, Ian McGilvray, Gary Levy, Anand Ghanekar, Eberhard Renner, David Grant, Laura Hawryluck, Markus Selzner – 10 April 2015 – Data regarding transplantation outcomes in ventilated intensive care unit (ICU)–dependent patients with end‐stage liver disease (ESLD) are conflicting. This single‐center cohort study investigated the outcomes of patients with ESLD who were intubated with mechanical support before liver transplantation (LT).

Optimizing repeat liver transplant graft utility through strategic matching of donor and recipient characteristics

Kenneth Hung, Jane Gralla, Jennifer L. Dodge, Kiran M. Bambha, Melisa Dirchwolf, Hugo R. Rosen, Scott W. Biggins – 10 April 2015 – Repeat liver transplantation (LT) is controversial because of inferior outcomes versus primary LT. A minimum 1‐year expected post–re‐LT survival of 50% has been proposed. We aimed to identify combinations of Model for End‐Stage Liver Disease (MELD), donor risk index (DRI), and recipient characteristics achieving this graft survival threshold.

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