Su Yin Lim, Alex Gordon‐Weeks, Danny Allen, Veerle Kersemans, John Beech, Sean Smart, Ruth J. Muschel – 8 April 2015 – Myeloid cells are known to mediate metastatic progression. Here, we attempted to elucidate the mechanisms underlying these effects by identifying gene expression alterations in cancer cells forming hepatic metastases after myeloid cell depletion. Hepatic metastases are heavily infiltrated by CD11b+ myeloid cells.

Douglas G. Mashek, Salmaan A. Khan, Aishwarya Sathyanarayan, Jonathan M. Ploeger, Mallory P. Franklin – 8 April 2015 – Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function.

Sofía De la Serna, Laura Llado, Emilio Ramos, Joan Fabregat, Carme Baliellas, Juli Busquets, Lluis Secanella, Nuria Pelaez, Jaume Torras, Antoni Rafecas – 8 April 2015 – Venous outflow is critical to the success of liver transplantation (LT). In domino liver transplantation (DLT), the venous cuffs should be shared between the donor and the recipient, and the length can be compromised. The aim of this study was to describe and compare the technical options for outflow reconstruction used at our institution.

Huey‐Ling Chen, Chien‐Nan Lee, Chin‐Hao Chang, Yen‐Hsuan Ni, Ming‐Kwang Shyu, Shih‐Ming Chen, Jen‐Jan Hu, Hans Hsienhong Lin, Lu‐Lu Zhao, Shu‐Chi Mu, Ming‐Wei Lai, Chyi‐Long Lee, Hsien‐Ming Lin, Ming‐Song Tsai, Jenn‐Jeih Hsu, Ding‐Shinn Chen, K. Arnold Chan, Mei‐Hwei Chang, Taiwan Study Group for the Prevention of Mother‐to‐Infant Transmission of HBV (PreMIT Study) – 7 April 2015 – The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother‐to‐infant hepatitis B virus (HBV) transmissions is not clearly understood.

Huey‐Ling Chen, Chien‐Nan Lee, Chin‐Hao Chang, Yen‐Hsuan Ni, Ming‐Kwang Shyu, Shih‐Ming Chen, Jen‐Jan Hu, Hans Hsienhong Lin, Lu‐Lu Zhao, Shu‐Chi Mu, Ming‐Wei Lai, Chyi‐Long Lee, Hsien‐Ming Lin, Ming‐Song Tsai, Jenn‐Jeih Hsu, Ding‐Shinn Chen, K. Arnold Chan, Mei‐Hwei Chang, Taiwan Study Group for the Prevention of Mother‐to‐Infant Transmission of HBV (PreMIT Study) – 7 April 2015 – The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother‐to‐infant hepatitis B virus (HBV) transmissions is not clearly understood.

Adeel A. Butt, Peng Yan, Hector Bonilla, Abdul‐Badi Abou‐Samra, Obaid S. Shaikh, Tracey G. Simon, Raymond T. Chung, Shari S. Rogal, for the ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team – 6 April 2015 – 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatment response, fibrosis progression, and hepatocellular carcinoma (HCC) incidence, with some having a more potent effect than others.

Stanislas Pol, Mark S. Sulkowski, Tarek Hassanein, Edward J. Gane, Lin Liu, Hongmei Mo, Brian Doehle, Bittoo Kanwar, Diana Brainard, G. Mani Subramanian, William T. Symonds, John G. McHutchison, Ronald G. Nahass, Michael Bennett, Ira M. Jacobson – 6 April 2015 – Retreatment of patients who have not achieved sustained virological response (SVR) after treatment with investigational direct‐acting antiviral agents (DAAs) has not been extensively studied.

Sharat Varma, Nicole Revencu, Xavier Stephenne, Isabelle Scheers, Françoise Smets, Ana Beleza‐Meireles, Raymond Reding, Tania Roskams, Etienne M. Sokal – 4 April 2015 – We investigated predictors of clinical evolution in progressive familial intrahepatic cholestasis type 2 patients and how they relate to bile salt export pump (BSEP) expression and its (re)targeting. Our retrospective study included 22 children with progressive familial intrahepatic cholestasis type 2.

K. Rajender Reddy, Marc Bourlière, Mark Sulkowski, Masao Omata, Stefan Zeuzem, Jordan J. Feld, Eric Lawitz, Patrick Marcellin, Tania M. Welzel, Robert Hyland, Xiao Ding, Jenny Yang, Steven Knox, Phillip Pang, Hadas Dvory‐Sobol, G. Mani Subramanian, William Symonds, John G. McHutchison, Alessandra Mangia, Edward Gane, Masashi Mizokami, Stanislas Pol, Nezam Afdhal – 4 April 2015 – Patients with hepatitis C virus (HCV) infection and cirrhosis are underrepresented in clinical trials of interferon‐free regimens of direct‐acting antiviral agents, making it difficult to optimize therapy.

Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl‐Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York – 4 April 2015 – Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression of Ca2+/calmodulin‐dependent protein kinase kinase 2 (CaMKK2) is significantly up‐regulated in hepatocellular carcinoma (HCC) and negatively correlated with HCC patient survival.