Transplantation speed offers early hepatocyte engraftment in acute liver injured rats: A translational study with clinical implications

Cheng‐Maw Ho, Ya‐Hui Chen, Chin‐Sung Chien, Yi‐Tian Ho, Shu‐Li Ho, Rey‐Heng Hu, Hui‐Ling Chen, Po‐Huang Lee – 26 March 2015 – The impact of the rate of intraportal hepatocyte transplantation on early engraftment and repopulation is unclear. The aim of this study was to address this and to improve the engraftment and repopulation efficiencies of hepatocyte transplantation for the treatment of a rat model of acute liver failure in a clinically useful way without preconditioning. Acute hepatic injury was induced into Sprague‐Dawley rats with D‐galactosamine.

Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice

Margaret A. Scull, Chao Shi, Ype P. de Jong, Gisa Gerold, Moritz Ries, Markus von Schaewen, Bridget M. Donovan, Rachael N. Labitt, Joshua A. Horwitz, Jenna M. Gaska, Gabriela Hrebikova, Jing W. Xiao, Brenna Flatley, Canny Fung, Luis Chiriboga, Christopher M. Walker, David T. Evans, Charles M. Rice, Alexander Ploss – 26 March 2015 – At least 170 million people are chronically infected with hepatitis C virus (HCV).

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