Ledipasvir‐sofosbuvir plus ribavirin for patients with genotype 1 hepatitis C virus previously treated in clinical trials of sofosbuvir regimens

David Wyles, Paul Pockros, Giuseppe Morelli, Ziad Younes, Evguenia Svarovskaia, Jenny C. Yang, Phillip S. Pang, Yanni Zhu, John G. McHutchison, Steven Flamm, Eric Lawitz – 2 April 2015 – Patients who fail to achieve sustained virological response (SVR) after treatment with sofosbuvir (SOF) plus ribavirin (RBV) with or without pegylated interferon (Peg‐IFN) do not have established retreatment options.

Increased risk of portal vein thrombosis in patients with cirrhosis due to nonalcoholic steatohepatitis

Jonathan G. Stine, Neeral L. Shah, Curtis K. Argo, Shawn J. Pelletier, Stephen H. Caldwell, Patrick G. Northup – 2 April 2015 – Portal vein thrombosis (PVT) is a common complication of cirrhosis sometimes implicated in hepatic decompensation. There are no consistent epidemiologic data to suggest an increased risk of thrombotic complications in nonalcoholic steatohepatitis (NASH); however, research suggests an increased risk of thrombosis.

Impact of Kasai portoenterostomy on liver transplantation outcomes: A retrospective cohort study of 347 children with biliary atresia

Joao Seda Neto, Flávia H. Feier, Ana Luiza Bierrenbach, Cristiana M. Toscano, Eduardo A. Fonseca, Renata Pugliese, Helry L. Candido, Marcel R. Benavides, Gilda Porta, Paulo Chapchap – 2 April 2015 – Biliary atresia (BA) is the main diagnosis leading to liver transplantation (LT) in children. When diagnosed early in life, a Kasai portoenterostomy (Kasai‐PE) can prevent or postpone LT. Instances of previous operations can result in difficulties during the LT. We hypothesized that a previous Kasai‐PE could affect LT outcomes.

Pulmonary nodules in liver transplant candidates with hepatocellular carcinoma: Imaging characteristics and clinical outcomes

Christopher Lee, Lauren Ihde, Andrew Kim, Idoia Santos, Lea Matsuoka, Yong Cen, Melissa Wallman, Edward Grant – 2 April 2015 – No guidelines exist for the management of pulmonary nodules in patients with hepatocellular carcinoma (HCC) who are being evaluated for liver transplantation. The 172 patients with HCC who were listed for liver transplant at our institution received both pretransplant chest computed tomography (CT) and follow‐up CT.

Enhanced liver fibrosis score predicts transplant‐free survival in primary sclerosing cholangitis

Mette Vesterhus, Johannes Roksund Hov, Anders Holm, Erik Schrumpf, Ståle Nygård, Kristin Godang, Ina Marie Andersen, Sigrid Næss, Douglas Thorburn, Francesca Saffioti, Morten Vatn, Odd Helge Gilja, Fridtjof Lund‐Johansen, Trygve Syversveen, Knut Brabrand, Albert Parés, Cyriel Y. Ponsioen, Massimo Pinzani, Martti Färkkilä, Bjørn Moum, Thor Ueland, Helge Røsjø, William Rosenberg, Kirsten Muri Boberg, Tom H. Karlsen – 1 April 2015 – There is a need to determine biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC).

Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma

Juling Ji, Tobias Eggert, Anuradha Budhu, Marshonna Forgues, Atsushi Takai, Hien Dang, Qinghai Ye, Ju‐Seog Lee, Ji Hoon Kim, Tim F. Greten, Xin Wei Wang – 1 April 2015 – Hepatocellular carcinoma (HCC) patients suffer from a poor survival rate and a high incidence of postoperative recurrence. The hepatic microenvironment plays a significant role in the initiation, progression, and recurrence of HCC; however, the causal mechanisms of these phenomena are unclear.

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