Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

Jasmohan S. Bajaj, Naga S. Betrapally, Phillip B. Hylemon, Douglas M. Heuman, Kalyani Daita, Melanie B. White, Ariel Unser, Leroy R. Thacker, Arun J. Sanyal, Dae Joong Kang, Masoumeh Sikaroodi, Patrick M Gillevet – 29 March 2015 – Altered gut microbiome is associated with systemic inflammation and cirrhosis decompensation. However, the correlation of the oral microbiome with inflammation in cirrhosis is unclear. Our aim was to evaluate the oral microbiome in cirrhosis and compare with stool microbiome.

MicroRNA‐494 is a master epigenetic regulator of multiple invasion‐suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors

Kuang‐Hsiang Chuang, Christa L. Whitney‐Miller, Chin‐Yi Chu, Zhongren Zhou, M. Katherine Dokus, Shannon Schmit, Christopher T. Barry – 29 March 2015 – Vascular invasion provides a direct route for tumor metastasis. The degree to which microRNA (miRNA) expression plays a role in tumor vascular invasion is unclear. Here, we report that miR‐494 is up‐regulated in human hepatocellular carcinoma (HCC) tumors with vascular invasion and can promote HCC cell invasiveness by gene inactivation of multiple invasion‐suppressor miRNAs.

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Karim J. Halazun, Rachel E. Patzer, Abbas A. Rana, Benjamin Samstein, Robert S. Brown, Jean C. Emond – 29 March 2015

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

Jasmohan S. Bajaj, Naga S. Betrapally, Phillip B. Hylemon, Douglas M. Heuman, Kalyani Daita, Melanie B. White, Ariel Unser, Leroy R. Thacker, Arun J. Sanyal, Dae Joong Kang, Masoumeh Sikaroodi, Patrick M Gillevet – 29 March 2015 – Altered gut microbiome is associated with systemic inflammation and cirrhosis decompensation. However, the correlation of the oral microbiome with inflammation in cirrhosis is unclear. Our aim was to evaluate the oral microbiome in cirrhosis and compare with stool microbiome.

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