Model for end‐stage liver disease‐based allocation system: On the right path, but not there yet
Ângelo Zambam de Mattos, Angelo Alves de Mattos – 22 March 2015
Re‐evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells
Thomas Vanwolleghem, Jun Hou, Gertine van Oord, Arno C. Andeweg, A.D.M.E. Osterhaus, Suzan D. Pas, Harry L.A. Janssen, Andre Boonstra – 22 March 2015 – To identify immunological mechanisms that govern distinct clinical phases of a chronic hepatitis B virus (HBV) infection—immune tolerant (IT), immune active (IA), inactive carrier (IC), and hepatitis B e antigen (HBeAg)‐negative (ENEG) hepatitis phases—we performed a systems biology study.
Nosocomial hepatitis C virus transmission from tampering with injectable anesthetic opioids
Rikita I. Hatia, Zoya Dimitrova, Pavel Skums, Elrond Yi‐Lang Teo, Chong‐Gee Teo – 22 March 2015 – The extent of provider‐to‐patient hepatitis C virus (HCV) transmission from diversion, self‐injection, and substitution (“tampering”) of anesthetic opioids is unknown. To quantify the contribution of opioid tampering to nosocomial HCV outbreaks, data from health care–related HCV outbreaks occurring in developed countries from 1990 to 2012 were collated, grouped, and compared. Tampering was associated with 17% (8 of 46) of outbreaks, but 53% (438 of 833) of cases.
Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes
Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.
Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes
Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.
Relationship between vitamin D status and response to hepatitis C virus therapy
Matthew T. Kitson, Christoph Sarrazin, Pierluigi Toniutto, Stuart K. Roberts – 21 March 2015
Liver inflammation abrogates immunological tolerance induced by Kupffer cells
Felix Heymann, Julia Peusquens, Isis Ludwig‐Portugall, Marlene Kohlhepp, Can Ergen, Patricia Niemietz, Christian Martin, Nico van Rooijen, Jordi C. Ochando, Gwendalyn J. Randolph, Tom Luedde, Florent Ginhoux, Christian Kurts, Christian Trautwein, Frank Tacke – 21 March 2015
Reply
Daniel Pineda‐Tenor, Mónica García‐Álvarez, María A. Jiménez‐Sousa, Amanda Fernández‐Rodríguez, Salvador Resino – 21 March 2015
Acute‐on‐chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults
Yu Shi, Ying Yang, Yaoren Hu, Wei Wu, Qiao Yang, Min Zheng, Shun Zhang, Zhaojun Xu, Yihua Wu, Huadong Yan, Zhi Chen – 20 March 2015 – Patients with acute‐on‐chronic liver failure (ACLF) represent a heterogeneous population. The aim of the study is to identify distinct groups according to the etiologies of precipitating events. A total of 405 ACLF patients were identified from 1,361 patients with cirrhosis with acute decompensation and categorized according to the types of acute insults.
Acute‐on‐chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults
Yu Shi, Ying Yang, Yaoren Hu, Wei Wu, Qiao Yang, Min Zheng, Shun Zhang, Zhaojun Xu, Yihua Wu, Huadong Yan, Zhi Chen – 20 March 2015 – Patients with acute‐on‐chronic liver failure (ACLF) represent a heterogeneous population. The aim of the study is to identify distinct groups according to the etiologies of precipitating events. A total of 405 ACLF patients were identified from 1,361 patients with cirrhosis with acute decompensation and categorized according to the types of acute insults.