Cilostazol improves hepatic blood perfusion, microcirculation, and liver regeneration after major hepatectomy in rats

Maximilian von Heesen, Stefan Dold, Simon Müller, Claudia Scheuer, Otto Kollmar, Martin K. Schilling, Michael D. Menger, Mohammed R. Moussavian – 13 March 2015 – Major hepatectomy or small‐for‐size liver transplantation may result in postoperative liver failure. So far, no treatment is available to improve liver regeneration. Herein, we studied whether cilostazol, a selective phosphodiesterase III inhibitor, is capable of improving liver regeneration after major hepatectomy.

Higher Mortality in registrants with sudden model for end‐stage liver disease increase: Disadvantaged by the current allocation policy

Allan B. Massie, Xun Luo, Jennifer L. Alejo, Anna K. Poon, Andrew M. Cameron, Dorry L. Segev – 12 March 2015 – Liver allocation is based on current Model for End‐Stage Liver Disease (MELD) scores, with priority in the case of a tie being given to those waiting the longest with a given MELD score. We hypothesized that this priority might not reflect risk: registrants whose MELD score has recently increased receive lower priority but might have higher wait‐list mortality. We studied wait‐list and posttransplant mortality in 69,643 adult registrants from 2002 to 2013.

Impact of anticoagulation on upper‐gastrointestinal bleeding in cirrhosis. A retrospective multicenter study

Federica Cerini, Javier Martínez Gonzalez, Ferran Torres, Ángela Puente, Meritxell Casas, Carmen Vinaixa, Marina Berenguer, Alba Ardevol, Salvador Augustin, Elba Llop, Maria Senosiaín, Càndid Villanueva, Joaquin de la Peña, Rafael Bañares, Joan Genescá, Júlia Sopeña, Agustín Albillos, Jaume Bosch, Virginia Hernández‐Gea, Juan Carlos Garcia‐Pagán – 12 March 2015 – Recent studies have shown that liver cirrhosis (LC) behaves as an acquired hypercoagulable state with increased thrombotic risk. This is why anticoagulation therapy (AT) is now frequently used in these patients.

Macrophage migration inhibitory factor as a potential predictor for requirement of renal replacement therapy after orthotopic liver transplantation

Joanna Stefaniak, Judith Schiefer, Edmund John Miller, Claus Georg Krenn, David Marek Baron, Peter Faybik – 11 March 2015 – Acute kidney injury (AKI) after orthotopic liver transplantation (OLT) is associated with a poor clinical outcome. Because there is no specific treatment for postoperative AKI, early recognition and prevention are fundamental therapeutic approaches. Concentrations of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) are elevated in patients with kidney disease.

Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers

Ravi Chhatrala, M. Bilal Siddiqui, R. Todd Stravitz, Carolyn Driscoll, Arun Sanyal, Carol Sargeant, Velimir Luketic, Amit Sharma, Richard Sterling, Scott Matherly, Puneet Puri, M. Shadab Siddiqui – 11 March 2015 – Although cardiovascular disease (CVD) is the leading cause of long‐term mortality in liver transplant recipients (LTRs), the role of recently identified biomarkers of CVD risk in liver transplantation is unknown. We aimed to evaluate an extensive CVD risk profile in LTRs.

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