Adaptation of the hepatitis B virus core protein to CD8+ T‐cell selection pressure

Helenie Kefalakes, Bettina Budeus, Andreas Walker, Christoph Jochum, Gudrun Hilgard, Andreas Heinold, Falko M. Heinemann, Guido Gerken, Daniel Hoffmann, Joerg Timm – 26 February 2015 – Activation of hepatitis B virus (HBV)–specific CD8 T cells by therapeutic vaccination may promote sustained control of viral replication by clearance of covalently closed circular DNA from infected hepatocytes. However, little is known about the exact targets of the CD8 T‐cell response and whether HBV reproducibly evades CD8 T‐cell immune pressure by mutation.

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