Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C‐X‐C chemokine receptor 4 axis

Oihane García‐Irigoyen, Maria U. Latasa, Simone Carotti, Iker Uriarte, Maria Elizalde, Raquel Urtasun, Umberto Vespasiani‐Gentilucci, Sergio Morini, Patricia Benito, Jose M. Ladero, Jose A. Rodriguez, Jesus Prieto, Josune Orbe, Jose A. Páramo, Maite G. Fernández‐Barrena, Carmen Berasain, Matias A. Avila – 23 March 2015 – Matrix metalloproteinases (MMPs) participate in tissue repair after acute injury, but also participate in cancer by promoting a protumorigenic microenvironment. Previously, we reported on a key role for MMP10 in mouse liver regeneration.

Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes

Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.

Microbial‐derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells–derived and fetal hepatocytes

Yishai Avior, Gahl Levy, Michal Zimerman, Daniel Kitsberg, Robert Schwartz, Ronen Sadeh, Arieh Moussaieff, Merav Cohen, Joseph Itskovitz‐Eldor, Yaakov Nahmias – 22 March 2015 – The liver is the main organ responsible for the modification, clearance, and transformational toxicity of most xenobiotics owing to its abundance in cytochrome P450 (CYP450) enzymes. However, the scarcity and variability of primary hepatocytes currently limits their utility.

Nosocomial hepatitis C virus transmission from tampering with injectable anesthetic opioids

Rikita I. Hatia, Zoya Dimitrova, Pavel Skums, Elrond Yi‐Lang Teo, Chong‐Gee Teo – 22 March 2015 – The extent of provider‐to‐patient hepatitis C virus (HCV) transmission from diversion, self‐injection, and substitution (“tampering”) of anesthetic opioids is unknown. To quantify the contribution of opioid tampering to nosocomial HCV outbreaks, data from health care–related HCV outbreaks occurring in developed countries from 1990 to 2012 were collated, grouped, and compared. Tampering was associated with 17% (8 of 46) of outbreaks, but 53% (438 of 833) of cases.

Re‐evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells

Thomas Vanwolleghem, Jun Hou, Gertine van Oord, Arno C. Andeweg, A.D.M.E. Osterhaus, Suzan D. Pas, Harry L.A. Janssen, Andre Boonstra – 22 March 2015 – To identify immunological mechanisms that govern distinct clinical phases of a chronic hepatitis B virus (HBV) infection—immune tolerant (IT), immune active (IA), inactive carrier (IC), and hepatitis B e antigen (HBeAg)‐negative (ENEG) hepatitis phases—we performed a systems biology study.

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

Su‐Yeon Lee, In‐Kyung Hong, Bo‐Rahm Kim, Soon‐Mi Shim, Jae Sung Lee, Hui‐Young Lee, Cheol Soo Choi, Bo‐Kyung Kim, Tae‐Sik Park – 22 March 2015 – The endoplasmic reticulum (ER) is the principal organelle in the cell for protein folding and trafficking, lipid synthesis, and cellular calcium homeostasis. Perturbation of ER function results in activation of the unfolded protein response (UPR) and is implicated in abnormal lipid biosynthesis and development of insulin resistance.

Reply

Daniel Pineda‐Tenor, Mónica García‐Álvarez, María A. Jiménez‐Sousa, Amanda Fernández‐Rodríguez, Salvador Resino – 21 March 2015

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