Fully laparoscopic left‐sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: A comparative study

Benjamin Samstein, Adam Griesemer, Daniel Cherqui, Tarek Mansour, Joseph Pisa, Anna Yegiants, Alyson N. Fox, James V. Guarrera, Tomoaki Kato, Karim J. Halazun, Jean Emond – 17 March 2015 – Living donor liver transplantation has failed to become a major means of transplantation in the United States, where <5% of the transplants are performed with living donors. At least 30% to 50% of the complications of donor hepatectomy appear to be related to abdominal wall trauma, including hernia, bowel obstruction, and chronic abdominal discomfort.

Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation

Roongruedee Chaiteerakij, Xiaodan Zhang, Benyam D. Addissie, Essa A. Mohamed, William S. Harmsen, Paul J. Theobald, Brian E. Peters, Joseph G. Balsanek, Melissa M. Ward, Nasra H. Giama, Catherine D. Moser, Abdul M. Oseini, Naoki Umeda, Sudhakar Venkatesh, Denise M. Harnois, Michael R. Charlton, Hiroyuki Yamada, Shinji Satomura, Alicia Algeciras‐Schimnich, Melissa R. Snyder, Terry M. Therneau, Lewis R. Roberts – 17 March 2015 – Growing evidence suggests that pretransplant alpha‐fetoprotein (AFP) predicts outcomes of hepatocellular carcinoma (HCC) patients treated with liver transplantation.

Total tumor volume and alpha‐fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation

Christian Toso, Glenda Meeberg, Roberto Hernandez‐Alejandro, Jean‐François Dufour, Paul Marotta, Pietro Majno, Norman M. Kneteman – 17 March 2015 – The selection of liver transplantation (LT) candidates with hepatocellular carcinoma (HCC) is currently validated based on Milan criteria. The use of extended criteria has remained a matter of debate, mainly because of the absence of prospective validation. The present prospective study recruited patients according to the previously proposed total tumor volume (TTV; ≤115 cm3)/alpha‐fetoprotein (AFP; ≤400 ng/mL) score.

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

Patrice N. Mimche, Lauren M. Brady, Christian F. Bray, Choon M. Lee, Manoj Thapa, Thayer P. King, Kendra Quicke, Courtney D. McDermott, Sylvie M. Mimche, Arash Grakoui, Edward T. Morgan, Tracey J. Lamb – 17 March 2015 – Beyond the well‐defined role of the Eph (erythropoietin‐producing hepatocellular) receptor tyrosine kinases in developmental processes, cell motility, cell trafficking/adhesion, and cancer, nothing is known about their involvement in liver pathologies.

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Constantine J. Karvellas, R. Todd Stravitz, Holly Battenhouse, William M. Lee, Michael L. Schilsky, for the US Acute Liver Failure Study Group – 16 March 2015

Patterns and predictors of sexual function after liver donation: The adult‐to‐adult living donor liver transplantation cohort study

Andrea F. DiMartini, Mary Amanda Dew, Zeeshan Butt, Mary Ann Simpson, Daniela P. Ladner, Abigail R. Smith, Peg Hill‐Callahan, Brenda W. Gillespie – 16 March 2015 – Although sexual functioning is an important facet of a living donor's quality of life, it has not received an extensive evaluation in this population. Using data from the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study, we examined donor sexual functioning across the donation process from the predonation evaluation to 3 months and 1 year after donation.

Decision support for organ offers in liver transplantation

Michael L. Volk, Nathan Goodrich, Jennifer C. Lai, Christopher Sonnenday, Kerby Shedden – 16 March 2015 – Organ offers in liver transplantation are high‐risk medical decisions with a low certainty of whether a better liver offer will come along before death. We hypothesized that decision support could improve the decision to accept or decline. With data from the Scientific Registry of Transplant Recipients, survival models were constructed for 42,857 waiting‐list patients and 28,653 posttransplant patients from 2002 to 2008.

Cilostazol improves hepatic blood perfusion, microcirculation, and liver regeneration after major hepatectomy in rats

Maximilian von Heesen, Stefan Dold, Simon Müller, Claudia Scheuer, Otto Kollmar, Martin K. Schilling, Michael D. Menger, Mohammed R. Moussavian – 13 March 2015 – Major hepatectomy or small‐for‐size liver transplantation may result in postoperative liver failure. So far, no treatment is available to improve liver regeneration. Herein, we studied whether cilostazol, a selective phosphodiesterase III inhibitor, is capable of improving liver regeneration after major hepatectomy.

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