Surakit Pungpapong, Bashar Aqel, Michael Leise, K. Tuesday Werner, Jennifer L. Murphy, Tanisha M. Henry, Kristen Ryland, Amy E. Chervenak, Kymberly D. Watt, Hugo E. Vargas, Andrew P. Keaveny – 26 February 2015 – Treatment with an all‐oral interferon‐free antiviral regimen using simeprevir and sofosbuvir with or without ribavirin (RBV) for 12 weeks resulted in high sustained virologic response (SVR) rates along with minimal adverse events in non–liver transplant (LT) patients with hepatitis C virus (HCV) genotype 1 infection.

Jian‐Hong Fang, Hui‐Chao Zhou, Chong Zhang, Li‐Ru Shang, Lei Zhang, Jing Xu, Limin Zheng, Yunfei Yuan, Rong‐Ping Guo, Wei‐Hua Jia, Jing‐Ping Yun, Min‐Shan Chen, Yaojun Zhang, Shi‐Mei Zhuang – 24 February 2015 – Early metastasis is responsible for frequent relapse and high mortality of hepatocellular carcinoma (HCC), but its underlying mechanisms remain unclear. Epithelial–mesenchymal transition (EMT) has been considered a key event in metastasis.

Richard Moreau, Emmanuel Weiss – 24 February 2015

Qilin Gu, Zongbin Cui – 24 February 2015

Mala Chakraborty, Aaron M. Fullerton, Kenrick Semple, Lynette S. Chea, William R. Proctor, Mohammed Bourdi, David E. Kleiner, Xiangbin Zeng, Pauline M. Ryan, Pradeep K. Dagur, Julia D. Berkson, Timothy P. Reilly, Lance R. Pohl – 24 February 2015 – Clinical evidence suggests that many cases of serious idiosyncratic drug‐induced liver injury are mediated by the adaptive immune system in response to hepatic drug‐protein adducts, also referred to as “drug‐induced allergic hepatitis”; but detailed mechanistic proof has remained elusive due to the lack of animal models.

Jian‐Hong Fang, Hui‐Chao Zhou, Chong Zhang, Li‐Ru Shang, Lei Zhang, Jing Xu, Limin Zheng, Yunfei Yuan, Rong‐Ping Guo, Wei‐Hua Jia, Jing‐Ping Yun, Min‐Shan Chen, Yaojun Zhang, Shi‐Mei Zhuang – 24 February 2015 – Early metastasis is responsible for frequent relapse and high mortality of hepatocellular carcinoma (HCC), but its underlying mechanisms remain unclear. Epithelial–mesenchymal transition (EMT) has been considered a key event in metastasis.

Ellen I. Closs – 24 February 2015

Manoj Thapa, Raghavan Chinnadurai, Victoria M. Velazquez, Dana Tedesco, Elizabeth Elrod, Jin‐Hwan Han, Prachi Sharma, Chris Ibegbu, Andrew Gewirtz, Frank Anania, Bali Pulendran, Mehul S. Suthar, Arash Grakoui – 24 February 2015 – Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote the profibrogenic activity of B cells. Fibrosis is completely attenuated in carbon tetrachloride–treated, B cell–deficient µMT mice, showing that B cells are required.

Wenjie Huang, Zhangqian Chen, Xin Shang, Dean Tian, Daowen Wang, Kaichun Wu, Daiming Fan, Limin Xia – 23 February 2015 – Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC) after curative resection. However, the molecular mechanism underlying HCC metastasis remains unclear. Here, we report on a novel function of SRY (sex determining region Y)‐box 12 (Sox12), a member of the SYR‐related high mobility group box family proteins, in promoting HCC metastasis.

Jude A. Oben – 23 February 2015