Human neonatal hepatocyte transplantation induces long‐term rescue of unconjugated hyperbilirubinemia in the Gunn rat
Laia Tolosa, Silvia López, Eugenia Pareja, María Teresa Donato, Anne Myara, Tuan Huy Nguyen, José Vicente Castell, María José Gómez‐Lechón – 30 March 2015 – Crigler‐Najjar type 1 disease is a rare inherited metabolic disease characterized by high levels of unconjugated bilirubin due to the complete absence of hepatic uridine diphosphoglucuronate–glucuronosyltransferase activity. Hepatocyte transplantation (HT) has been proposed as an alternative treatment for Crigler‐Najjar syndrome, but it is still limited by the quality and the low engraftment and repopulation ability of the cells used.