Reproducibility of mRECIST in assessing response to transarterial radioembolization therapy in hepatocellular carcinoma

Adeel R. Seyal, Fernanda D. Gonzalez‐Guindalini, Atilla Arslanoglu, Carla B. Harmath, Robert J. Lewandowski, Riad Salem, Vahid Yaghmai – 22 May 2015 – The purpose of our study was to evaluate the reproducibility of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) in hepatocellular carcinoma (HCC) lesions undergoing transarterial radioembolization (TARE) therapy and to determine whether mRECIST reproducibility is affected by the enhancement pattern of HCC. One hundred and three HCC lesions from 103 patients treated with TARE were evaluated.

Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.

Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.

Involvement of a cyclic adenosine monophosphate–dependent signal in the diet‐induced canalicular trafficking of adenosine triphosphate–binding cassette transporter g5/g8

Yasuhiro Yamazaki, Kenta Yasui, Takahiro Hashizume, Arisa Suto, Ayaka Mori, Yuzuki Murata, Masahiko Yamaguchi, Akira Ikari, Junko Sugatani – 22 May 2015 – The adenosine triphosphate–binding cassette (ABC) half‐transporters Abcg5 and Abcg8 promote the secretion of neutral sterol into bile. Studies have demonstrated the diet‐induced gene expression of these transporters, but the regulation of their trafficking when the nutritional status changes in the liver remains to be elucidated.

Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial‐mesenchymal transition

Zhi‐Chao Wang, Qiang Gao, Jie‐Yi Shi, Wei‐Jie Guo, Liu‐Xiao Yang, Xin‐Yang Liu, Long‐Zi Liu, Li‐Jie Ma, Meng Duan, Ying‐Jun Zhao, Yong‐Na Wu, Dong‐Mei Gao, Xiao‐Ying Wang, Guo‐Ming Shi, Zhen‐Bin Ding, Ai‐Wu Ke, Qi‐Qun Tang, Ya Cao, Jian Zhou, Jia Fan – 22 May 2015 – Hepatocellular carcinoma (HCC) is the third‐most lethal cancer worldwide. Understanding the molecular pathogenesis of HCC recurrence and metastasis is the key to improve patients’ prognosis.

Rejection triggers liver transplant tolerance: Involvement of mesenchyme‐mediated immune control mechanisms in mice

Miwa Morita, Daniel Joyce, Charles Miller, John J. Fung, Lina Lu, Shiguang Qian – 22 May 2015 – Liver tolerance was initially recognized by the spontaneous acceptance of liver allografts in many species. The underlying mechanisms are not completely understood. However, liver transplant (LT) tolerance absolutely requires interferon (IFN)‐γ, a rejection‐associated inflammatory cytokine.

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