Optimizing informed consent in living liver donors: Evaluation of a comprehension assessment tool

Elisa J. Gordon, Jack Mullee, Zeeshan Butt, Joseph Kang, Talia Baker – 19 May 2015 – Adult‐to‐adult living liver donation is associated with considerable risks with no direct medical benefit to liver donors (LDs). Ensuring that potential LDs comprehend the risks of donation is essential to medically and ethically justify the procedure. We developed and prospectively evaluated the initial psychometrics of an “Evaluation of Donor Informed Consent Tool” (EDICT) designed to assess LDs' comprehension about the living donation process.

Cost‐effectiveness of liver transplantation in methylmalonic and propionic acidemias

Meng Li, Andre Dick, Martin Montenovo, Simon Horslen, Ryan Hansen – 19 May 2015 – Propionic acidemia (PA) and classical methylmalonic acidemia (MMA) are rare inborn errors of metabolism that can cause early mortality and significant morbidity. The mainstay of disease management is lifelong protein restriction. As an alternative, liver transplantation (LT) may improve survival, quality of life, and prevent further neurological deterioration. The aim of our study was to estimate the incremental costs and outcomes of LT versus nutritional support in patients with early‐onset MMA or PA.

Biliary complications in pediatric liver transplantation: Incidence and management over a decade

Jerome M. Laurence, Gonzalo Sapisochin, Maria DeAngelis, John B. Seal, Mar M. Miserachs, Max Marquez, Murtuza Zair, Annie Fecteau, Nicola Jones, Alexander Hrycko, Yaron Avitzur, Simon C. Ling, Vicky Ng, Mark Cattral, David Grant, Binita M. Kamath, Anand Ghanekar – 19 May 2015 – This study analyzed how features of a liver graft and the technique of biliary reconstruction interact to affect biliary complications in pediatric liver transplantation. A retrospective analysis was performed of data collected from 2001 to 2011 in a single high‐volume North American pediatric transplant center.

Liver sharing and organ procurement organization performance under redistricted allocation

Sommer E. Gentry, Eric K. H. Chow, Allan Massie, Xun Luo, Eugene Shteyn, Joshua Pyke, David Zaun, Jon J. Snyder, Ajay K. Israni, Bert Kasiske, Dorry L. Segev – 19 May 2015 – Concerns have been raised that optimized redistricting of liver allocation areas might have the unintended result of shifting livers from better‐performing to poorer‐performing organ procurement organizations (OPOs). We used liver simulated allocation modeling to simulate a 5‐year period of liver sharing within either 4 or 8 optimized districts.

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Susan Holtzman, Hance A. Clarke, Stuart A. McCluskey, Kara Turcotte, David Grant, Joel Katz – 19 May 2015

A multicenter study of 30 days complications after deceased donor liver transplantation in the model for end‐stage liver disease score era

Anup Parikh, Kenneth W. Washburn, Lea Matsuoka, Urvashi Pandit, Jennifer E. Kim, Jose Almeda, Cesar Mora‐Esteves, Glenn Halff, Yuri Genyk, Bart Holland, Dorian J. Wilson, Linda Sher, Baburao Koneru – 19 May 2015 – Knowledge of risk factors for posttransplant complications is likely to improve patient outcomes. Few large studies of all early postoperative complications after deceased donor liver transplantation (DDLT) exist. Therefore, we conducted a retrospective, cohort study of 30‐day complications, their risk factors, and the impact on outcomes after DDLT.

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