Patients with chronic hepatitis B should be screened for hepatocellular carcinoma regardless of liver stiffness measurement
Philippe Sultanik, Philippe Sogni, Jean‐François Meritet, Stanislas Pol, Vincent Mallet – 23 May 2015
Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice
Young Suk Jo, Dongryeol Ryu, Adriano Maida, Xu Wang, Ronald M. Evans, Kristina Schoonjans, Johan Auwerx – 22 May 2015 – Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide‐ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator‐activated receptor alpha (PPARα) upon feeding, thereby blunting ketogenesis.
Pathological polyploidy in liver disease
Shu‐hao Hsu, Andrew W. Duncan – 22 May 2015
Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury
Seung‐Hyun Kim, Katy Saide, John Farrell, Lee Faulkner, Arun Tailor, Monday Ogese, Ann K. Daly, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt – 22 May 2015 – Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease. The aim of this study was to investigate whether drug‐responsive T lymphocytes are detectable in patients who developed DILI with the combination, antimicrobial amoxicillin‐clavulanate.
Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver
Iina Tuominen, Simon W. Beaven – 22 May 2015
Reproducibility of mRECIST in assessing response to transarterial radioembolization therapy in hepatocellular carcinoma
Adeel R. Seyal, Fernanda D. Gonzalez‐Guindalini, Atilla Arslanoglu, Carla B. Harmath, Robert J. Lewandowski, Riad Salem, Vahid Yaghmai – 22 May 2015 – The purpose of our study was to evaluate the reproducibility of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) in hepatocellular carcinoma (HCC) lesions undergoing transarterial radioembolization (TARE) therapy and to determine whether mRECIST reproducibility is affected by the enhancement pattern of HCC. One hundred and three HCC lesions from 103 patients treated with TARE were evaluated.
Salivary microbiota‐immune profiling in cirrhosis: Could this be the noninvasive strategy that will revolutionize prognostication in hepatology?
Vishal C. Patel, Debbie L. Shawcross – 22 May 2015
Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.
Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Todt, Paula Monteiro Perin, Patrick Behrendt, Florian W.R. Vondran, Shuting Xu, Christine Goffinet, Luis M. Schang, Markus H. Heim, Ralf Bartenschlager, Thomas Pietschmann, Eike Steinmann – 22 May 2015 – Hepatitis C virus (HCV) is a positive‐strand RNA virus that primarily infects human hepatocytes. Infections with HCV constitute a global health problem, with 180 million people currently chronically infected.
Involvement of a cyclic adenosine monophosphate–dependent signal in the diet‐induced canalicular trafficking of adenosine triphosphate–binding cassette transporter g5/g8
Yasuhiro Yamazaki, Kenta Yasui, Takahiro Hashizume, Arisa Suto, Ayaka Mori, Yuzuki Murata, Masahiko Yamaguchi, Akira Ikari, Junko Sugatani – 22 May 2015 – The adenosine triphosphate–binding cassette (ABC) half‐transporters Abcg5 and Abcg8 promote the secretion of neutral sterol into bile. Studies have demonstrated the diet‐induced gene expression of these transporters, but the regulation of their trafficking when the nutritional status changes in the liver remains to be elucidated.