Chuan‐chuan Zhou, Fu Yang, Sheng‐xian Yuan, Jin‐zhao Ma, Feng Liu, Ji‐hang Yuan, Feng‐rui Bi, Kong‐ying Lin, Jian‐hua Yin, Guang‐wen Cao, Wei‐ping Zhou, Fang Wang, Shu‐han Sun – 13 December 2015 – Systemic analyses using large‐scale genomic profiles have successfully identified cancer‐driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in “protein‐coding gene desert” regions are largely unknown.

Christophe Cassinotto, Jérome Boursier, Victor de Lédinghen, Jérome Lebigot, Bruno Lapuyade, Paul Cales, Jean‐Baptiste Hiriart, Sophie Michalak, Brigitte Le Bail, Victoire Cartier, Amaury Mouries, Frédéric Oberti, Isabelle Fouchard‐Hubert, Julien Vergniol, Christophe Aubé – 13 December 2015 – Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue.

Xi Lan, Jidong Yan, Juan Ren, Bo Zhong, Jing Li, Yue Li, Li Liu, Jing Yi, Qingzhu Sun, Xudong Yang, Jian Sun, Liesu Meng, Wenhua Zhu, Rikard Holmdahl, Dongmin Li, Shemin Lu – 11 December 2015 – Cholesterol metabolism disorder in hepatocytes predicts a higher risk of metabolic syndrome (MetS). Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are not systematically clarified.

Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Giulio Marchesini, Salvatore Petta, Riccardo Dalle Grave – 11 December 2015 – Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal.

Ding‐Shinn Chen, Yun‐Fan Liaw, Chien‐Jen Chen, Jaw‐Ching Wu, Wan‐Long Chuang, Cheng‐Yuan Peng, Rong‐Nan Chien – 10 December 2015

Dominik Wieland, Robert Thimme – 10 December 2015

Angelo Sangiovanni, Massimo Colombo – 10 December 2015

Tung‐Hung Su, Chun‐Jen Liu, Tai‐Chung Tseng, Shih‐Wan Chou, Chen‐Hua Liu, Hung‐Chih Yang, Shang‐Ju Wu, Pei‐Jer Chen, Ding‐Shinn Chen, Chi‐Ling Chen, Jia‐Horng Kao – 10 December 2015 – Chronic hepatitis C viral (HCV) infection has been associated with non‐Hodgkin's lymphoma (NHL); however, the results are inconsistent among regions with different HCV prevalence rates. The temporal relationship, risk estimates, and association between HCV and lymphoid‐neoplasms remain unclear.

Richard Gilroy, John Bucuvalas – 10 December 2015