End‐ischemic machine perfusion reduces bile duct injury in donation after circulatory death rat donor livers independent of the machine perfusion temperature

Andrie C. Westerkamp, Paria Mahboub, Sophie L. Meyer, Maximilia Hottenrott, Petra J. Ottens, Janneke Wiersema‐Buist, Annette S. H. Gouw, Ton Lisman, Henri G. D. Leuvenink, Robert J. Porte – 19 June 2015 – A short period of oxygenated machine perfusion (MP) after static cold storage (SCS) may reduce biliary injury in donation after cardiac death (DCD) donor livers. However, the ideal perfusion temperature for protection of the bile ducts is unknown. In this study, the optimal perfusion temperature for protection of the bile ducts was assessed.

The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial

Salvatore Piano, Silvano Fasolato, Freddy Salinas, Antonietta Romano, Marta Tonon, Filippo Morando, Marta Cavallin, Elisabetta Gola, Antonietta Sticca, Arianna Loregian, Giorgio Palù, Giacomo Zanus, Marco Senzolo, Patrizia Burra, Umberto Cillo, Paolo Angeli – 18 June 2015 – Spontaneous bacterial peritonitis (SBP) is a common, life‐threatening complication of liver cirrhosis. Third‐generation cephalosporins have been considered the first‐line treatment of SBP.

The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial

Salvatore Piano, Silvano Fasolato, Freddy Salinas, Antonietta Romano, Marta Tonon, Filippo Morando, Marta Cavallin, Elisabetta Gola, Antonietta Sticca, Arianna Loregian, Giorgio Palù, Giacomo Zanus, Marco Senzolo, Patrizia Burra, Umberto Cillo, Paolo Angeli – 18 June 2015 – Spontaneous bacterial peritonitis (SBP) is a common, life‐threatening complication of liver cirrhosis. Third‐generation cephalosporins have been considered the first‐line treatment of SBP.

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

Lily Dara, Heather Johnson, Jo Suda, Sanda Win, William Gaarde, Derick Han, Neil Kaplowitz – 16 June 2015 – Although necrosis in the acetaminophen (APAP) model is known to be regulated by c‐Jun NH2‐terminal kinase (JNK) through interaction with mitochondria, the role of necroptosis through receptor‐interacting proteins 1 and 3 (RIPK1 and RIPK3) has also been suggested. Our aim was to determine the relationship between these two mechanisms of cell death.

Intrapulmonary vascular dilatations are common in portopulmonary hypertension and may be associated with decreased survival

Lynn A. Fussner, Vivek N. Iyer, Rodrigo Cartin‐Ceba, Grace Lin, Kymberly D. Watt, Michael J. Krowka – 16 June 2015 – Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (POPH) are pulmonary vascular complications of portal hypertension with divergent clinicopathologic features and management. The presence of intrapulmonary vascular dilatations (IPVDs), detected by agitated saline contrast‐enhanced transthoracic echocardiography (cTTE), is an essential feature of HPS but is not typically characteristic of POPH.

Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR‐338‐3p‐PKLR axis in hepatocellular carcinoma

Huizhen Nie, Jun Li, Xiao‐Mei Yang, Qing‐Zhen Cao, Ming‐Xuan Feng, Feng Xue, Lin Wei, Wenxin Qin, Jianren Gu, Qiang Xia, Zhi‐Gang Zhang – 16 June 2015 – Hormones and their corresponding receptors are vital in controlling metabolism under normal physiologic and pathologic conditions, but less is known about their roles in the metabolism of cancer.

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