Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

Yinying Lu, Wanping Xu, Junfang Ji, Dechun Feng, Carole Sourbier, Youfeng Yang, Jianhui Qu, Zhen Zeng, Chunping Wang, Xiujuan Chang, Yan Chen, Alok Mishra, Max Xu, Min‐Jung Lee, Sunmin Lee, Jane Trepel, W. Marston Linehan, Xinwei Wang, Yongping Yang, Len Neckers – 8 June 2015 – The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced, with one isoform containing a long proline‐rich region (PRRL) compared to the other with a short PRR (PRRS). Recently, PRRL was reported to enhance proliferation of breast and lung cancer cells.

MiR‐199a‐5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer

Weijie Guo, Zhaoping Qiu, Zhichao Wang, Qifeng Wang, Ning Tan, Taoyang Chen, Zhiao Chen, Shenglin Huang, Jianren Gu, Jinjun Li, Ming Yao, Yingjun Zhao, Xianghuo He – 5 June 2015 – Cancer cells possess a unique metabolic phenotype that allows them to preferentially utilize glucose through aerobic glycolysis. This phenomenon is referred to as the “Warburg effect.” Accumulating evidence suggests that microRNAs (miRNAs), a class of small noncoding regulatory RNAs, interact with oncogenes/tumor suppressors and induce such metabolic reprograming in cancer cells.

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

James H. Tabibian, Steven P. O'Hara, Christy E. Trussoni, Pamela S. Tietz, Patrick L. Splinter, Taofic Mounajjed, Lee R. Hagey, Nicholas F. LaRusso – 4 June 2015 – Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure. We tested the hypothesis that germ‐free (GF) mutltidrug resistance 2 knockout (mdr2−/−) mice develop a distinct PSC phenotype, compared to conventionally housed (CV) mdr2−/− mice.

Subscribe to