Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury

Man Li, Albert Mennone, Carol J. Soroka, Lee R. Hagey, Xinshou Ouyang, Edward J. Weinman, James L. Boyer – 25 June 2015 – The intercellular adhesion molecule 1 (ICAM‐1) is induced in mouse liver after bile duct ligation (BDL) and plays a key role in neutrophil‐mediated liver injury in BDL mice. ICAM‐1 has been shown to interact with cytoskeletal ezrin‐radixin‐moesin (ERM) proteins that also interact with the PDZ protein, Na+/H+ exchanger regulatory factor 1 (NHERF‐1/EBP50). In NHERF‐1−/− mice, ERM proteins are significantly reduced in brush‐border membranes from kidney and small intestine.

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin‐1

Lucía Barbier‐Torres, Naiara Beraza, Pablo Fernández‐Tussy, Fernando Lopitz‐Otsoa, David Fernández‐Ramos, Imanol Zubiete‐Franco, Marta Varela‐Rey, Teresa C. Delgado, Virginia Gutiérrez, Juan Anguita, Albert Pares, Jesús M. Banales, Erica Villa, Juan Caballería, Luis Alvarez, Shelly C. Lu, Jose M. Mato, María Luz Martínez‐Chantar – 25 June 2015 – Prohibitin‐1 (PHB1) is an evolutionarily conserved pleiotropic protein that participates in diverse processes depending on its subcellular localization and interactome.

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