Temoporfin improves efficacy of photodynamic therapy in advanced biliary tract carcinoma: A multicenter prospective phase II study

Andrej Wagner, Ulrike W. Denzer, Daniel Neureiter, Tobias Kiesslich, Andreas Puespoeck, Erik A.J. Rauws, Klaus Emmanuel, Nora Degenhardt, Ulrich Frick, Ulrich Beuers, Ansgar W. Lohse, Frieder Berr, Gernot W. Wolkersdörfer – 20 May 2015 – Photodynamic therapy using porfimer (P‐PDT) improves palliation and survival in nonresectable hilar bile duct cancer. Tumoricidal penetration depth of temoporfin‐PDT (T‐PDT) is twice that of P‐PDT. In a single‐arm phase II study we investigated the safety, efficacy, survival time, and adverse events of T‐PDT compared with previous data on P‐PDT.

Renal function improvement in liver transplant recipients after early everolimus conversion: A clinical practice cohort study in Spain

Itxarone Bilbao, Magdalena Salcedo, Miguel Angel Gómez, Carlos Jimenez, Javier Castroagudín, Joan Fabregat, Carolina Almohalla, Ignacio Herrero, Valentín Cuervas‐Mons, Alejandra Otero, Angel Rubín, Manuel Miras, Juan Rodrigo, Trinidad Serrano, Gonzalo Crespo, Manuel De la Mata, Javier Bustamante, M. Luisa Gonzalez‐Dieguez, Antonia Moreno, Isidoro Narvaez, Magda Guilera, for the EVEROLIVER study group – 19 May 2015 – A national, multicenter, retrospective study was conducted to assess the results obtained for liver transplant recipients with conversion to everolimus in daily practice.

The recipient celiac trunk as an alternative to the native hepatic artery for arterial reconstruction in adult liver transplantation

Safi Dokmak, Béatrice Aussilhou, Filippo Landi, Fédérica Dondéro, Salah Termos, Cathérine Paugam‐Burtz, François Durand, Jacques Belghiti – 19 May 2015 – During liver transplantation (LT), the recipient hepatic artery (RHA) cannot always be used, and alternatives include aortohepatic conduits and the splenic artery (SA). We report our experience with arterial reconstruction on the recipient celiac trunk (RCT), which has rarely been described. Since January 2013, we have been using the RCT when the RHA could not be used.

Optimizing informed consent in living liver donors: Evaluation of a comprehension assessment tool

Elisa J. Gordon, Jack Mullee, Zeeshan Butt, Joseph Kang, Talia Baker – 19 May 2015 – Adult‐to‐adult living liver donation is associated with considerable risks with no direct medical benefit to liver donors (LDs). Ensuring that potential LDs comprehend the risks of donation is essential to medically and ethically justify the procedure. We developed and prospectively evaluated the initial psychometrics of an “Evaluation of Donor Informed Consent Tool” (EDICT) designed to assess LDs' comprehension about the living donation process.

Cost‐effectiveness of liver transplantation in methylmalonic and propionic acidemias

Meng Li, Andre Dick, Martin Montenovo, Simon Horslen, Ryan Hansen – 19 May 2015 – Propionic acidemia (PA) and classical methylmalonic acidemia (MMA) are rare inborn errors of metabolism that can cause early mortality and significant morbidity. The mainstay of disease management is lifelong protein restriction. As an alternative, liver transplantation (LT) may improve survival, quality of life, and prevent further neurological deterioration. The aim of our study was to estimate the incremental costs and outcomes of LT versus nutritional support in patients with early‐onset MMA or PA.

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