When to perform hepatic resection for intermediate‐stage hepatocellular carcinoma

Alessandro Cucchetti, Benjamin Djulbegovic, Athanasios Tsalatsanis, Alessandro Vitale, Iztok Hozo, Fabio Piscaglia, Matteo Cescon, Giorgio Ercolani, Francesco Tuci, Umberto Cillo, Antonio Daniele Pinna – 21 July 2014 – Transcatheter arterial chemoembolization (TACE) is the first‐line therapy recommended for patients with intermediate hepatocellular carcinoma (HCC). However, in clinical practice, these patients are often referred to surgical teams to be evaluated for hepatectomy.

Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections

Barbara Rehermann, Antonio Bertoletti – 21 July 2014 – Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause a large proportion of acute and chronic liver disease worldwide. Over the past decades many immunological studies defined host immune responses that mediate spontaneous clearance of acute HBV and HCV infection. However, host immune responses are also relevant in the context of treatment‐induced clearance of chronic HBV and HCV infection.

Reciprocal activation between ATPase inhibitory factor 1 and NF‐κB drives hepatocellular carcinoma angiogenesis and metastasis

Ruipeng Song, Huiwen Song, Yingjian Liang, Dalong Yin, Heng Zhang, Tongsen Zheng, Jiabei Wang, Zhaoyang Lu, Xuan Song, Tiemin Pei, Youyou Qin, Yuejin Li, Changming Xie, Boshi Sun, Huawen Shi, Shuai Li, Xianzhi Meng, Guangchao Yang, Shangha Pan, Jiyuan Zhu, Shuyi Qi, Hongchi Jiang, Zhiyong Zhang, Lianxin Liu – 14 July 2014

Effect of social support and donation‐related concerns on ambivalence of living liver donor candidates

Yun‐Chieh Lai, Wei‐Chen Lee, Yeong‐Yuh Juang, Lee‐Lan Yen, Li‐Chueh Weng, Hsueh Fen Chou – 13 July 2014 – Ambivalence in the decision‐making process for living liver donors has the potential to result in their experiencing a negative mental status. To promote donor candidates' well‐being, it is important to study the factors related to ambivalence. Thus, the aim of this study was to explore the ambivalence of living liver donor candidates and to investigate the effect of social support and donation‐related concerns on their ambivalence. A cross‐sectional design was used.

LI‐RADS (Liver Imaging Reporting and Data System): Summary, discussion, and consensus of the LI‐RADS Management Working Group and future directions

Donald G. Mitchell, Jordi Bruix, Morris Sherman, Claude B. Sirlin – 12 July 2014 – To improve standardization and consensus regarding performance, interpreting, and reporting computed tomography (CT) and magnetic resonance imaging (MRI) examinations of the liver in patients at risk for hepatocellular carcinoma (HCC), LI‐RADS (Liver Imaging Reporting and Data System) was launched in March 2011 and adopted by many clinical practices throughout the world.

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