EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR‐dependent stabilization of MDM4 in hepatocellular carcinoma

Rossella Pellegrino, Diego F. Calvisi, Olaf Neumann, Venkatesh Kolluru, Josephine Wesely, Xin Chen, Chunmei Wang, Torsten Wuestefeld, Sara Ladu, Nahla Elgohary, Justo Lorenzo Bermejo, Bernhard Radlwimmer, Martin Zörnig, Lars Zender, Frank Dombrowski, Matthias Evert, Peter Schirmacher, Thomas Longerich – 28 November 2013 – Mouse Double Minute homolog 4 (MDM4) gene up‐regulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood.

Secretory leukocyte protease inhibitor: A pivotal mediator of anti‐inflammatory responses in acetaminophen‐induced acute liver failure

Charalambos Gustav Antoniades, Wafa Khamri, Robin D. Abeles, Leonie S. Taams, Evangelos Triantafyllou, Lucia A. Possamai, Christine Bernsmeier, Ragai R. Mitry, Alistair O'Brien, Derek Gilroy, Robert Goldin, Michael Heneghan, Nigel Heaton, Wayel Jassem, William Bernal, Diego Vergani, Yun Ma, Alberto Quaglia, Julia Wendon, Mark Thursz – 27 November 2013 – Acetaminophen‐induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis.

Secretory leukocyte protease inhibitor: A pivotal mediator of anti‐inflammatory responses in acetaminophen‐induced acute liver failure

Charalambos Gustav Antoniades, Wafa Khamri, Robin D. Abeles, Leonie S. Taams, Evangelos Triantafyllou, Lucia A. Possamai, Christine Bernsmeier, Ragai R. Mitry, Alistair O'Brien, Derek Gilroy, Robert Goldin, Michael Heneghan, Nigel Heaton, Wayel Jassem, William Bernal, Diego Vergani, Yun Ma, Alberto Quaglia, Julia Wendon, Mark Thursz – 27 November 2013 – Acetaminophen‐induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis.

Evidence for serotonin as a relevant inducer of liver regeneration after liver resection in humans

Patrick Starlinger, Alice Assinger, Stefanie Haegele, David Wanek, Silvia Zikeli, Dominic Schauer, Peter Birner, Edith Fleischmann, Birgit Gruenberger, Christine Brostjan, Thomas Gruenberger – 26 November 2013 – Liver regeneration (LR) involves a complex interplay of growth factors and antagonists. In this context, platelet‐derived serotonin (5‐HT) has been identified as a critical inducer of LR in mice. Clinical evidence for a role of 5‐HT in LR in humans is lacking.

The architecture of diagnostic research: From bench to bedside—research guidelines using liver stiffness as an example

Agostino Colli, Mirella Fraquelli, Giovanni Casazza, Dario Conte, Dimitrinka Nikolova, Piergiorgio Duca, Kristian Thorlund, Christian Gluud – 26 November 2013 – The diagnostic research process can be divided into five phases, designed to establish the clinical utility of a new diagnostic test—the index test. The aim of the present review is to illustrate the study designs that are appropriate for each diagnostic phase, using clinical examples regarding liver fibrosis diagnosed with transient elastography, when possible.

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

Song‐iee Han, Yoko Komatsu, Akiko Murayama, Knut R. Steffensen, Yoshimi Nakagawa, Yuka Nakajima, Michiko Suzuki, Shohei Oie, Paolo Parini, Lise‐Lotte Vedin, Hiroyuki Kishimoto, Hitoshi Shimano, Jan‐Åke Gustafsson, Junn Yanagisawa – 26 November 2013 – Liver X receptor (LXR) activation stimulates triglyceride (TG) accumulation in the liver. Several lines of evidence indicate that estradiol‐17β (E2) reduces TG levels in the liver; however, the molecular mechanism underlying the E2 effect remains unclear.

The architecture of diagnostic research: From bench to bedside—research guidelines using liver stiffness as an example

Agostino Colli, Mirella Fraquelli, Giovanni Casazza, Dario Conte, Dimitrinka Nikolova, Piergiorgio Duca, Kristian Thorlund, Christian Gluud – 26 November 2013 – The diagnostic research process can be divided into five phases, designed to establish the clinical utility of a new diagnostic test—the index test. The aim of the present review is to illustrate the study designs that are appropriate for each diagnostic phase, using clinical examples regarding liver fibrosis diagnosed with transient elastography, when possible.

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