Re‐evaluation of the predictive score for 6‐month graft survival in living donor liver transplantation in the modern era

Tomoharu Yoshizumi, Toru Ikegami, Yuki Bekki, Mizuki Ninomiya, Hideaki Uchiyama, Tomohiro Iguchi, Yo‐Ichi Yamashita, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara – 29 November 2013 – The limitations of donor age, graft size, and the Model for End‐Stage Liver Disease (MELD) score have not been apparent in living donor liver transplantation (LDLT). Our team developed a formula for predicting graft survival after LDLT; the formula includes the graft weight, donor age, MELD score, and portosystemic shunt status.

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR‐dependent stabilization of MDM4 in hepatocellular carcinoma

Rossella Pellegrino, Diego F. Calvisi, Olaf Neumann, Venkatesh Kolluru, Josephine Wesely, Xin Chen, Chunmei Wang, Torsten Wuestefeld, Sara Ladu, Nahla Elgohary, Justo Lorenzo Bermejo, Bernhard Radlwimmer, Martin Zörnig, Lars Zender, Frank Dombrowski, Matthias Evert, Peter Schirmacher, Thomas Longerich – 28 November 2013 – Mouse Double Minute homolog 4 (MDM4) gene up‐regulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood.

Secretory leukocyte protease inhibitor: A pivotal mediator of anti‐inflammatory responses in acetaminophen‐induced acute liver failure

Charalambos Gustav Antoniades, Wafa Khamri, Robin D. Abeles, Leonie S. Taams, Evangelos Triantafyllou, Lucia A. Possamai, Christine Bernsmeier, Ragai R. Mitry, Alistair O'Brien, Derek Gilroy, Robert Goldin, Michael Heneghan, Nigel Heaton, Wayel Jassem, William Bernal, Diego Vergani, Yun Ma, Alberto Quaglia, Julia Wendon, Mark Thursz – 27 November 2013 – Acetaminophen‐induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis.

Secretory leukocyte protease inhibitor: A pivotal mediator of anti‐inflammatory responses in acetaminophen‐induced acute liver failure

Charalambos Gustav Antoniades, Wafa Khamri, Robin D. Abeles, Leonie S. Taams, Evangelos Triantafyllou, Lucia A. Possamai, Christine Bernsmeier, Ragai R. Mitry, Alistair O'Brien, Derek Gilroy, Robert Goldin, Michael Heneghan, Nigel Heaton, Wayel Jassem, William Bernal, Diego Vergani, Yun Ma, Alberto Quaglia, Julia Wendon, Mark Thursz – 27 November 2013 – Acetaminophen‐induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis.

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