Reframing the impact of combined heart‐liver allocation on liver transplant wait‐list candidates

David S. Goldberg, Peter P. Reese, Sandra Amaral, Peter L. Abt – 11 July 2014 – Simultaneous heart‐liver (H‐L) transplantation, although rare, has become more common in the United States. When the primary organ is a heart or liver, patients receiving an offer for the primary organ automatically receive the second, nonprimary organ from that donor. This policy raises issues of equity, such as whether liver transplantation alone candidates bypassed by H‐L recipients are disadvantaged.

Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration

Jingling Jin, Il‐Hwa Hong, Kyle Lewis, Polina Iakova, Meghan Breaux, Yanjun Jiang, Emily Sullivan, Nicole Jawanmardi, Lubov Timchenko, Nikolai A. Timchenko – 9 July 2014 – Liver cancer is the fifth most common cancer. A highly invasive surgical resection of the liver tumor is the main approach used to eliminate the tumor. Mechanisms that terminate liver regeneration when the liver reaches the original size are not known.

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

Thomas H.R. Carlsen, Jannie Pedersen, Jannick C. Prentoe, Erick Giang, Zhen‐Yong Keck, Lotte S. Mikkelsen, Mansun Law, Steven K.H. Foung, Jens Bukh – 8 July 2014 – Human monoclonal antibodies (HMAbs) with neutralizing capabilities constitute potential immune‐based treatments or prophylaxis against hepatitis C virus (HCV). However, lack of cell culture‐derived HCV (HCVcc) harboring authentic envelope proteins (E1/E2) has hindered neutralization investigations across genotypes, subtypes, and isolates.

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