Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell‐cycle control and apoptosis

Ulrike A. Köhler, Svitlana Kurinna, Dominik Schwitter, Andrea Marti, Matthias Schäfer, Claus Hellerbrand, Tobias Speicher, Sabine Werner – 6 December 2013 – The nuclear factor erythroid‐derived 2, like 2 (Nrf2) transcription factor is a key regulator of the antioxidant defense system, and pharmacological activation of Nrf2 is a promising strategy for prevention of toxin‐induced liver damage. However, the consequences of Nrf2 activation on liver regeneration (LR) have not been determined.

Nationwide survey of the outcomes of living donor liver transplantation for hepatoblastoma in Japan

Seisuke Sakamoto, Mureo Kasahara, Koichi Mizuta, Tatsuo Kuroda, Takahito Yagi, Tomoaki Taguchi, Yukihiro Inomata, Koji Umeshita, Shinji Uemoto, for the Japanese Liver Transplantation Society – 29 November 2013 – Recently, liver transplantation (LT) has been increasingly performed for unresectable hepatoblastoma (HB) with acceptable results. We conducted a national survey of cases undergoing living donor liver transplantation (LDLT) for HB to evaluate their outcomes.

Re‐evaluation of the predictive score for 6‐month graft survival in living donor liver transplantation in the modern era

Tomoharu Yoshizumi, Toru Ikegami, Yuki Bekki, Mizuki Ninomiya, Hideaki Uchiyama, Tomohiro Iguchi, Yo‐Ichi Yamashita, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara – 29 November 2013 – The limitations of donor age, graft size, and the Model for End‐Stage Liver Disease (MELD) score have not been apparent in living donor liver transplantation (LDLT). Our team developed a formula for predicting graft survival after LDLT; the formula includes the graft weight, donor age, MELD score, and portosystemic shunt status.

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR‐dependent stabilization of MDM4 in hepatocellular carcinoma

Rossella Pellegrino, Diego F. Calvisi, Olaf Neumann, Venkatesh Kolluru, Josephine Wesely, Xin Chen, Chunmei Wang, Torsten Wuestefeld, Sara Ladu, Nahla Elgohary, Justo Lorenzo Bermejo, Bernhard Radlwimmer, Martin Zörnig, Lars Zender, Frank Dombrowski, Matthias Evert, Peter Schirmacher, Thomas Longerich – 28 November 2013 – Mouse Double Minute homolog 4 (MDM4) gene up‐regulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood.

Subscribe to