Flipping the switch
31 July 2013
Rebleeding prophylaxis improves outcomes in patients with hepatocellular carcinoma. A multicenter case‐control study
Cristina Ripoll, Joan Genescà, Isis K. Araujo, Isabel Graupera, Salvador Augustin, Marta Tejedor, Isabel Cirera, Carles Aracil, Margarita Sala, Manuel Hernandez‐Guerra, Elba Llop, Angels Escorsell, Maria Vega Catalina, Nuria Cañete, Agustin Albillos, Càndid Villanueva, Juan G. Abraldes, Rafael Bañares, Jaime Bosch – 31 July 2013 – Outcome of variceal bleeding (VB) in patients with hepatocellular carcinoma (HCC) is unknown. We compared outcomes after VB in patients with and without HCC. All patients with HCC and esophageal VB admitted between 2007 and 2010 were included.
Healthcare costs associated with hepatocellular carcinoma and the value of care
Lorenzo G. Mantovani, Mario Strazzabosco – 31 July 2013
Chronic hepatitis E in an immunocompetent patient: A case report
Priya Grewal, Saleem Kamili, David Motamed – 31 July 2013
Sublethal heat treatment promotes epithelial‐mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma
Jiwen Cheng, MuXing Li, Yi Lv – 31 July 2013
Healthcare costs associated with hepatocellular carcinoma and the value of care
Lorenzo G. Mantovani, Mario Strazzabosco – 31 July 2013
Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis
Ragunath Singaravelu, Ran Chen, Rodney K. Lyn, Daniel M. Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S. Russell, D. Lorne Tyrrell, John Paul Pezacki – 29 July 2013 – MicroRNAs (miRNAs) are small RNAs that posttranscriptionally regulate gene expression. Their aberrant expression is commonly linked with diseased states, including hepatitis C virus (HCV) infection. Herein, we demonstrate that HCV replication induces the expression of miR‐27 in cell culture and in vivo HCV infectious models.
Risk factors for long‐term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults
Kiyoaki Ito, Hiroshi Yotsuyanagi, Hiroshi Yatsuhashi, Yoshiyasu Karino, Yasuhiro Takikawa, Takafumi Saito, Yasuji Arase, Fumio Imazeki, Masayuki Kurosaki, Takeji Umemura, Takafumi Ichida, Hidenori Toyoda, Masashi Yoneda, Eiji Mita, Kazuhide Yamamoto, Kojiro Michitaka, Tatsuji Maeshiro, Junko Tanuma, Yasuhito Tanaka, Masaya Sugiyama, Kazumoto Murata, Naohiko Masaki, Masashi Mizokami, the Japanese AHB Study Group – 29 July 2013 – The proportion of patients who progress to chronicity following acute hepatitis B (AHB) varies widely worldwide.
Growth arrest and DNA damage 45G down‐regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma
Li Zhang, Zhaojuan Yang, Aihui Ma, Yulan Qu, Suhua Xia, Dongxu Xu, Chao Ge, Bijun Qiu, Qiang Xia, Jinjun Li, Yongzhong Liu – 29 July 2013 – Growth arrest and DNA damage 45G (GADD45G), a stress sensor with multiple implications in various biological processes, is down‐regulated in a broad spectrum of cancers. However, little is known about the biological effects of GADD45G on hepatocellular carcinoma (HCC) cells and the related mechanisms. In the present study, we found that GADD45G was commonly down‐regulated in oncogene‐transformed mouse liver cells and in human and mouse HCC.
Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis
Ragunath Singaravelu, Ran Chen, Rodney K. Lyn, Daniel M. Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S. Russell, D. Lorne Tyrrell, John Paul Pezacki – 29 July 2013 – MicroRNAs (miRNAs) are small RNAs that posttranscriptionally regulate gene expression. Their aberrant expression is commonly linked with diseased states, including hepatitis C virus (HCV) infection. Herein, we demonstrate that HCV replication induces the expression of miR‐27 in cell culture and in vivo HCV infectious models.