Xiang‐Dan Cui, Mi‐Jin Lee, Jong‐Hyun Kim, Pei‐Pei Hao, Lan Liu, Goung‐Ran Yu, Dae‐Ghon Kim – 11 January 2013 – Eph receptor 2 (EphA2) overexpression is frequently accompanied by the loss of its cognate ligand during tumor progression. However, the molecular mechanism of this ligand‐independent promotion of tumor by EphA2 remains unclear in highly malignant and fatal cholangiocarcinoma (CC). We examined the biological role of EphA2 in tumor growth and metastasis in CC tissues and cells according to the degree of differentiation and we explored the downstream signaling pathways of EphA2.

Michael R. Kraus, Arne Schäfer, Gerlinde Teuber, Heiner Porst, Kathrin Sprinzl, Sven Wollschläger, Christian Keicher, Michael Scheurlen – 8 January 2013 – Earlier studies have suggested neurocognitive impairment in patients with chronic hepatitis C virus (HCV) infection even before liver cirrhosis has developed. Since these deficits might be reversible after successful antiviral therapy, we analyzed the long‐term course of neurocognitive parameters in HCV patients with and without successful virus elimination by an interferon‐based antiviral treatment.

Stephanie Coulon, Vanessa Legry, Femke Heindryckx, Christophe Van Steenkiste, Christophe Casteleyn, Kim Olievier, Louis Libbrecht, Peter Carmeliet, Bart Jonckx, Jean‐Marie Stassen, Hans Van Vlierberghe, Isabelle Leclercq, Isabelle Colle, Anja Geerts – 8 January 2013 – The pathophysiology of nonalcoholic steatohepatitis (NASH) should be approached as a multifactorial process. In several stages of NASH, a link between disease progression and hepatic microvasculature changes can be made.

Didier Samuel, Jean‐Charles Duclos‐Vallee – 8 January 2013

Marzena Swiderska‐Syn, Ayako Suzuki, Cynthia D. Guy, Jeffrey B. Schwimmer, Manal F. Abdelmalek, Joel E. Lavine, Anna Mae Diehl – 8 January 2013

Lars P. Bechmann, Peri Kocabayoglu, Jan‐Peter Sowa, Svenja Sydor, Jan Best, Martin Schlattjan, Anja Beilfuss, Johannes Schmitt, Rebekka A. Hannivoort, Alpaslan Kilicarslan, Christian Rust, Frieder Berr, Oliver Tschopp, Guido Gerken, Scott L. Friedman, Andreas Geier, Ali Canbay – 8 January 2013 – Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and may proceed to steatohepatitis (NASH). Apoptosis and free fatty acid (FFA)‐induced lipotoxicity are important features of NASH pathogenesis.

8 January 2013

Lucas J. Maillette de Buy Wenniger, Marieke E. Doorenspleet, Paul L. Klarenbeek, Joanne Verheij, Frank Baas, Ronald P. Oude Elferink, Paul P. Tak, Niek de Vries, Ulrich Beuers – 8 January 2013 – Immunoglobulin G4 (IgG4)‐associated cholangitis (IAC) is a manifestation of the recently discovered idiopathic IgG4‐related disease. The majority of patients have elevated serum IgG4 levels and/or IgG4‐positive B‐cell and plasma cell infiltrates in the affected tissue.

Svitlana Kurinna, Sabrina A. Stratton, Zeynep Coban, Jill M. Schumacher, Markus Grompe, Andrew W. Duncan, Michelle Craig Barton – 8 January 2013 – Functions of p53 during mitosis reportedly include prevention of polyploidy and transmission of aberrant chromosomes. However, whether p53 plays these roles during genomic surveillance in vivo and, if so, whether this is done via direct or indirect means remain unknown. The ability of normal, mature hepatocytes to respond to stimuli, reenter the cell cycle, and regenerate liver mass offers an ideal setting to assess mitosis in vivo.

Hla‐Hla Thein, Wanrudee Isaranuwatchai, Michael A. Campitelli, Jordan J. Feld, Eric Yoshida, Morris Sherman, Jeffrey S. Hoch, Stuart Peacock, Murray D. Krahn, Craig C. Earle – 8 January 2013 – Although the burden of hepatocellular carcinoma (HCC) is an escalating public health problem, it has not been rigorously estimated within a Canadian context. We conducted a population‐based study using Ontario Cancer Registry linked administrative data. The mean net costs of care due to HCC were estimated using a phase of care approach and generalized estimating equations.