Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease

Bryan D. Maliken, James E. Nelson, Heather M. Klintworth, Mary Beauchamp, Matthew M. Yeh, Kris V. Kowdley – 16 January 2013 – The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and cell death in nonalcoholic fatty liver disease (NAFLD). Clinical, biochemical, metabolic, and independent histopathologic assessment was conducted in 83 unselected patients with biopsy‐proven NAFLD from a single center.

Decreased iron burden in overweight C282Y homozygous women: Putative role of increased hepcidin production

Romain Desgrippes, Fabrice Lainé, Jeff Morcet, Michèle Perrin, Ghislain Manet, Caroline Jezequel, Edouard Bardou‐Jacquet, Martine Ropert, Yves Deugnier – 15 January 2013 – An excess of visceral adipose tissue could be involved as a modulator of the penetrance of HFE hemochromatosis since fat mass is associated with overexpression of hepcidin and low transferrin saturation was found to be associated with being overweight in women.

Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis

Toshiya Kamiyama, Hideki Yokoo, Jun‐Ichi Furukawa, Masaki Kurogochi, Tomoaki Togashi, Nobuaki Miura, Kazuaki Nakanishi, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Masato Fujiyoshi, Akinobu Taketomi, Shin‐Ichiro Nishimura, Satoru Todo – 15 January 2013 – The altered N‐glycosylation of glycoproteins has been suggested to play an important role in the behavior of malignant cells. Using glycomics technology, we attempted to determine the specific and detailed N‐glycan profile for hepatocellular carcinoma (HCC) and investigate the prognostic capabilities.

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice

Justin R. Henning, Christopher S. Graffeo, Adeel Rehman, Nina C. Fallon, Constantinos P. Zambirinis, Atsuo Ochi, Rocky Barilla, Mohsin Jamal, Michael Deutsch, Stephanie Greco, Melvin Ego‐Osuala, Usama Bin‐Saeed, Raghavendra S. Rao, Sana Badar, Juan P. Quesada, Devrim Acehan, George Miller – 15 January 2013 – Nonalcoholic steatohepatitis (NASH) is the most common etiology of chronic liver dysfunction in the United States and can progress to cirrhosis and liver failure. Inflammatory insult resulting from fatty infiltration of the liver is central to disease pathogenesis.

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B

Katharina Esser‐Nobis, Inés Romero‐Brey, Tom M. Ganten, Jérôme Gouttenoire, Christian Harak, Rahel Klein, Peter Schemmer, Marco Binder, Paul Schnitzler, Darius Moradpour, Ralf Bartenschlager, Stephen J. Polyak, Wolfgang Stremmel, François Penin, Christoph Eisenbach, Volker Lohmann – 15 January 2013 – Intravenous silibinin (SIL) is an approved therapeutic that has recently been applied to patients with chronic hepatitis C, successfully clearing hepatitis C virus (HCV) infection in some patients even in monotherapy.

Sustained hepatitis C virus clearance and increased hepatitis B surface antigen seroclearance in patients with dual chronic hepatitis C and B during posttreatment follow‐up

Ming‐Lung Yu, Chuan‐Mo Lee, Chi‐Ling Chen, Wan‐Long Chuang, Sheng‐Nan Lu, Chen‐Hua Liu, Shun‐Sheng Wu, Li‐Ying Liao, Hsing‐Tao Kuo, You‐Chen Chao, Shui‐Yi Tung, Sien‐Sing Yang, Jia‐Horng Kao, Wei‐Wen Su, Chih‐Lin Lin, Hung‐Chih Yang, Pei‐Jer Chen, Ding‐Shinn Chen, Chun‐Jen Liu, for the Taiwan Liver‐Net Consortium – 15 January 2013 – Patients dually infected with hepatitis C virus (HCV)/hepatitis B virus (HBV) have a higher risk of developing advanced liver disease or hepatocellular carcinoma compared with monoinfected patients.

Genome‐wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor‐beta signaling

Wei Wei, Juan Hou, Olivia Alder, Xin Ye, Sam Lee, Rebecca Cullum, Andy Chu, Yongjun Zhao, Stephanie M. Warner, Darryl A. Knight, Decheng Yang, Steven J.M. Jones, Marco A. Marra, Pamela A. Hoodless – 12 January 2013 – MicroRNAs (miRNAs) are recently discovered small RNA molecules that regulate developmental processes, such as proliferation, differentiation, and apoptosis; however, the identity of miRNAs and their functions during liver development are largely unknown.

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