Ina Rittelmeyer, Michael Rothe, Martijn H. Brugman, Marcus Iken, Axel Schambach, Michael P. Manns, Christopher Baum, Ute Modlich, Michael Ott – 19 December 2012 – Lentiviral (LV) vectors are promising tools for long‐term genetic correction of hereditary diseases. In hematopoietic stem cell gene therapies adverse events in patients due to vector integration‐associated genotoxicity have been observed. Only a few studies have explored the potential risks of LV gene therapy targeting the liver.

Yu‐Tzu Tseng, Sui‐Yuan Chang, Wen‐Chun Liu, Hsin‐Yun Sun, Cheng‐Hsin Wu, Pei‐Ying Wu, Ching‐Lan Lu, Chien‐Ching Hung, Shan‐Chwen Chang – 19 December 2012 – The purpose of this prospective cohort study was to compare the serologic response between human immunodeficiency virus (HIV)‐infected men who have sex with men (MSM) receiving two and three doses of hepatitis A virus (HAV) vaccine and HIV‐uninfected MSM receiving two doses of HAV vaccine. Between June 2009 and December 2010, 582 MSM aged 18 to 40 years who were seronegative for HAV were enrolled in the study.

Sanjoy Roychowdhury, Megan R. McMullen, Sorana G. Pisano, Xiuli Liu, Laura E. Nagy – 14 December 2012 – Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol‐induced liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol‐induced hepatocyte injury or inflammation. Because receptor‐interacting protein kinase (RIP) 3–mediated necroptosis, a nonapoptotic cell death pathway, is implicated in a variety of pathological conditions, we tested the hypothesis that ethanol‐induced liver injury is RIP3‐dependent and RIP1‐independent.

Gregory T. Everson, John C. Hoefs, Claus U. Niemann, Kim M. Olthoff, Robert Dupuis, Shannon Lauriski, Andrea Herman, Norah Milne, Brenda W. Gillespie, Nathan P. Goodrich, James E. Everhart – 13 December 2012 – We quantified the rates of hepatic regeneration and functional recovery for 6 months after right hepatic lobectomy in living donors for liver transplantation.

Flavia H. Feier, Joao Seda Neto, Gilda Porta, Eduardo A. Fonseca, Rodrigo Vincenzi, Helry L. Cândido, Marcel Benavides, Bernardo Ketzer, Renata Pugliese, Irene K. Miura, Vera Baggio, Teresa Guimarães, Adriana Porta, Gustavo Foronda, Enis Donizete, Jose P. da Silva, Lucilia Faria, Mario Kondo, Paulo Chapchap – 13 December 2012 – The association of biliary atresia (BA) with congenital heart diseases has been extensively described, and there are a number of reports on the outcomes of patients in this group who undergo liver transplantation (LT).

William R. Proctor, Mala Chakraborty, Lynette S. Chea, Jeffrey C. Morrison, Julia D. Berkson, Kenrick Semple, Mohammed Bourdi, Lance R. Pohl – 12 December 2012 – Drug‐induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease. This is due in part to the lack of animal models and knowledge of susceptibility factors that predispose individuals to DILI. In this regard, liver eosinophilia has often been associated with DILI, although its role remains unclear.

Brian R. Edlin – 12 December 2012 – Hepatitis C is the most prevalent bloodborne viral disease in the United States and the deadliest. This year, the U.S. Preventive Services Task Force (USPSTF) will update its 2004 hepatitis C guideline, which recommends against screening asymptomatic adults for hepatitis C. This guideline has hampered public health efforts to encourage screening and identify and refer infected persons for care by declaring that such interventions were not supported by the evidence.

Jin‐feng Huang, Ying‐jun Guo, Chen‐xi Zhao, Sheng‐xian Yuan, Yue Wang, Guan‐nan Tang, Wei‐ping Zhou, Shu‐han Sun – 12 December 2012 – The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long noncoding RNAs (lncRNAs), which regulate gene expression with little or no protein‐coding capacity, are involved in diverse biological processes and in carcinogenesis.

Cleide G. da Silva, Peter Studer, Marco Skroch, Jerome Mahiou, Darlan C. Minussi, Clayton R. Peterson, Suzhuei W. Wilson, Virendra I. Patel, Averil Ma, Eva Csizmadia, Christiane Ferran – 12 December 2012 – Liver regeneration is of major clinical importance in the setting of liver injury, resection, and transplantation. A20, a potent antiinflammatory and nuclear factor kappa B (NF‐κB) inhibitory protein, has established pro‐proliferative properties in hepatocytes, in part through decreasing expression of the cyclin dependent kinase inhibitor, p21.

Safa Al‐Shamma, Balint Eross, Simon Mclaughlin – 12 December 2012