The FDA, bridging data, and hepatitis C
Michael W. Fried, Donald M. Jensen – 29 November 2012
Clinical experience with microdialysis catheters in pediatric liver transplants
Håkon Haugaa, Runar Almaas, Ebbe Billmann Thorgersen, Aksel Foss, Pål Dag Line, Truls Sanengen, Gísli Björn Bergmann, Per Ohlin, Lars Wælgaard, Guro Grindheim, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 29 November 2012 – Ischemic vascular complications and rejection occur more frequently with pediatric liver transplants versus adult liver transplants. Using intrahepatic microdialysis catheters, we measured lactate, pyruvate, glucose, and glycerol values at the bedside for a median of 10 days in 20 pediatric liver grafts.
Mesenchymal Stem Cells Overexpressing C‐X‐C Chemokine Receptor Type 4 Improve Early Liver Regeneration of Small‐for‐Size Liver Grafts
Zhiyong Du, Cuifeng Wei, Jiqi Yan, Baosan Han, Mingjun Zhang, Chenghong Peng, Yingbin Liu – 29 November 2012 – Mesenchymal stem cell (MSC) therapy can prevent hepatic parenchymal cell loss and promote tissue repair. However, poor MSC engraftment is one of the primary barriers to the effectiveness of cell therapy because culture‐expanded MSCs progressively down‐regulate C‐X‐C chemokine receptor type 4 (CXCR4) expression and lose their ability to migrate toward a concentration gradient of stromal cell–derived factor 1a (SDF1a).
Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1‐antitrypsin deficiency
Adriana Ordóñez, Erik L. Snapp, Lu Tan, Elena Miranda, Stefan J. Marciniak, David A. Lomas – 29 November 2012 – Point mutants of alpha1‐antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. These inclusions cause cell damage and predispose to ER stress in the absence of the classical unfolded protein response (UPR).
The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection: Are the data found in this sample applicable to other settings?
Catiane Tiecher Cusinato, Ana Paula Messa Koetz, Nêmora Tregnago Barcellos, Fernando Herz Wolff – 29 November 2012
National survey of provider opinions on controversial characteristics of liver transplant candidates
Katharine Secunda, Elisa J. Gordon, Min W. Sohn, Laura A. Shinkunas, Lauris C. Kaldjian, Michael D. Voigt, Josh Levitsky – 29 November 2012 – Candidate selection for liver transplantation presents challenging ethical issues that require balancing the principles of justice and utility. The goal of this study was to assess the opinions of US transplant providers regarding the ways in which controversial medical and psychosocial characteristics influence patient eligibility for liver transplantation.
Hepatitis C Virus–Associated Cholestatic Hepatitis: We Cannot Seem to Agree on Diagnostic Criteria
Marina Berenguer, Geoffrey McCaughan – 29 November 2012
Deceased Organ Donor Research: The Last Research Frontier?
Thomas Mone, John Heldens, Claus U. Niemann – 29 November 2012
Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: National data from Japan
Kenichi Harada, Junko Hirohara, Yoshiyuki Ueno, Toshiaki Nakano, Yuko Kakuda, Hirohito Tsubouchi, Takafumi Ichida, Yasuni Nakanuma – 29 November 2012 – Primary biliary cirrhosis (PBC) primarily affects females and is rarely complicated by hepatocellular carcinoma (HCC). Although the HCC incidence in PBC patients is low, several characteristics and risk factors associated with its development have been reported. In this study, national data concerning the current status of carcinogenesis in PBC patients in Japan are reviewed.
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George N. Ioannou, Christopher L. Bryson, Noel S. Weiss, John D. Scott, Edward J. Boyko – 29 November 2012