Hepatocyte caspase‐8 is an essential modulator of steatohepatitis in rodents

Maximilian Hatting, Gang Zhao, Fabienne Schumacher, Gernot Sellge, Malika Al Masaoudi, Nikolaus Gaβler, Mark Boekschoten, Michael Müller, Christian Liedtke, Francisco Javier Cubero, Christian Trautwein – 21 January 2013 – In human and murine models of nonalcoholic steatohepatitis (NASH), increased hepatocyte apoptosis is a critical mechanism contributing to inflammation and fibrogenesis. Caspase 8 (Casp8) is essential for death‐receptor‐mediated apoptosis activity and therefore its modulation might be critical for the pathogenesis of NASH.

MAT2B‐GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer

Hui Peng, Lily Dara, Tony W.H. Li, Yuhua Zheng, Heping Yang, Maria Lauda Tomasi, Ivan Tomasi, Pasquale Giordano, Jose M. Mato, Shelly C. Lu – 16 January 2013 – Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1 and V2) that promote cell growth. Using in‐solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1) was identified as a potential interacting partner of MAT2B. Here, we examined the functional significance of this interplay. Coimmunoprecipitation experiments examined protein interactions.

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