Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the milan criteria in transplantable hepatocellular carcinoma: A retrospective analysis based on tissue microarrays

Ju Hyun Shim, Han Chu Lee, Seungbong Han, Hyo Jeong Kang, Eunsil Yu, Sung‐Gyu Lee – 2 December 2012 – We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. The expression of alpha‐fetoprotein (AFP), HNF1α, and HNF1β was examined with immunohistochemistry on duplicate tissue microarray slides containing HCC tumor explants.

Early and Long‐Term Results of Routine Microsurgical Biliary Reconstruction in Living Donor Liver Transplantation

Tsan‐Shiun Lin, Chao‐Long Chen, Allan M. Concejero, Anthony Q. Yap, Yu‐Hung Lin, Chun‐Yi Liu, Yuan‐Cheng Chiang, Chih‐Chi Wang, Shih‐Ho Wang, Chih‐Che Lin, Chee‐Chien Yong, Yu‐Fan Cheng – 29 November 2012 – We describe our early and long‐term experience with routine biliary reconstruction via a microsurgical technique in living donor liver transplantation (LDLT). One hundred seventy‐seven grafts (including 3 dual grafts) were primarily transplanted into 174 recipients. The minimum follow‐up was 44 months.

Liver‐specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice

Ana M. Tormos, Alessandro Arduini, Raquel Talens‐Visconti, Ivan del Barco Barrantes, Angel R. Nebreda, Juan Sastre – 29 November 2012 – p38α mitogen‐activated protein kinases (MAPK) may be essential in the up‐regulation of proinflammatory cytokines and can be activated by transforming growth factor β, tumor necrosis factor‐α, interleukin‐1β, and oxidative stress. p38 MAPK activation results in hepatocyte growth arrest, whereas increased proliferation has been considered a hallmark of p38α‐deficient cells.

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George N. Ioannou, Christopher L. Bryson, Noel S. Weiss, John D. Scott, Edward J. Boyko – 29 November 2012

Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: National data from Japan

Kenichi Harada, Junko Hirohara, Yoshiyuki Ueno, Toshiaki Nakano, Yuko Kakuda, Hirohito Tsubouchi, Takafumi Ichida, Yasuni Nakanuma – 29 November 2012 – Primary biliary cirrhosis (PBC) primarily affects females and is rarely complicated by hepatocellular carcinoma (HCC). Although the HCC incidence in PBC patients is low, several characteristics and risk factors associated with its development have been reported. In this study, national data concerning the current status of carcinogenesis in PBC patients in Japan are reviewed.

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