Yi‐Ming Tao, Jin‐Lin Huang, Shan Zeng, Sai Zhang, Xue‐Gong Fan, Zhi‐Ming Wang, Hui‐Xiang Yang, Xiao‐Hua Yuan, Pu Wang, Fan Wu, Jia Luo, De‐Yu Zeng, Hong Shen – 16 January 2013 – Epithelial‐mesenchymal transition (EMT) is a critical step in the metastasis of hepatocellular carcinoma (HCC). BTB/POZ domain‐containing protein 7 (BTBD7) regulates EMT‐associated proteins implicated in HCC progression. However, the role(s) of BTBD7 in HCC have not been identified.

Su Mi Choi, Yonghak Kim, Joong Sup Shim, Joon Tae Park, Rui‐Hong Wang, Steven D. Leach, Jun O. Liu, Chuxia Deng, Zhaohui Ye, Yoon‐Young Jang – 16 January 2013 – Patient‐specific induced pluripotent stem cells (iPSCs) represent a potential source for developing novel drug and cell therapies. Although increasing numbers of disease‐specific iPSCs have been generated, there has been limited progress in iPSC‐based drug screening/discovery for liver diseases, and the low gene‐targeting efficiency in human iPSCs warrants further improvement.

Boris Görg, Hans‐Jürgen Bidmon, Dieter Häussinger – 16 January 2013 – Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is seen as the clinical manifestation of a low‐grade cerebral edema associated with oxidative‐nitrosative stress. However, comprehensive data on HE‐associated molecular derangements in the human brain are lacking. In the present study, we used a whole human genome microarray approach for gene expression profiling in post mortem brain samples from patients with cirrhosis with or without HE and controls without cirrhosis.

Jason Grebely, Jordan J. Feld, Tanya Applegate, Gail V. Matthews, Margaret Hellard, Alana Sherker, Kathy Petoumenos, Geng Zang, Ineke Shaw, Barbara Yeung, Jacob George, Suzy Teutsch, John M. Kaldor, Vera Cherepanov, Julie Bruneau, Naglaa H. Shoukry, Andrew R. Lloyd, Gregory J. Dore – 16 January 2013 – Systemic levels of interferon‐gamma‐inducible protein‐10 (IP‐10) are predictive of treatment‐induced clearance in chronic hepatitis C virus (HCV).

Kristin A. Moy, Li Jiao, Neal D. Freedman, Stephanie J. Weinstein, Rashmi Sinha, Jarmo Virtamo, Demetrius Albanes, Rachael Z. Stolzenberg‐Solomon – 16 January 2013 – Binding of advanced glycation end products (AGEs) to their receptor (RAGE) increases oxidative stress and inflammation and may be involved in liver injury and subsequent carcinogenesis. Soluble RAGE (sRAGE) may neutralize the effects mediated by the AGE/RAGE complex. Epidemiologic studies examining sRAGE or AGEs in association with liver cancer are lacking.

Feng Wang, Shu‐Zhi Zhao, Ming‐Yue Zhang, Yan‐Lei Ma, Peng Zhang, Huan‐Long Qin – 16 January 2013

Bryan D. Maliken, James E. Nelson, Heather M. Klintworth, Mary Beauchamp, Matthew M. Yeh, Kris V. Kowdley – 16 January 2013 – The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and cell death in nonalcoholic fatty liver disease (NAFLD). Clinical, biochemical, metabolic, and independent histopathologic assessment was conducted in 83 unselected patients with biopsy‐proven NAFLD from a single center.

Romain Desgrippes, Fabrice Lainé, Jeff Morcet, Michèle Perrin, Ghislain Manet, Caroline Jezequel, Edouard Bardou‐Jacquet, Martine Ropert, Yves Deugnier – 15 January 2013 – An excess of visceral adipose tissue could be involved as a modulator of the penetrance of HFE hemochromatosis since fat mass is associated with overexpression of hepcidin and low transferrin saturation was found to be associated with being overweight in women.

Toshiya Kamiyama, Hideki Yokoo, Jun‐Ichi Furukawa, Masaki Kurogochi, Tomoaki Togashi, Nobuaki Miura, Kazuaki Nakanishi, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Masato Fujiyoshi, Akinobu Taketomi, Shin‐Ichiro Nishimura, Satoru Todo – 15 January 2013 – The altered N‐glycosylation of glycoproteins has been suggested to play an important role in the behavior of malignant cells. Using glycomics technology, we attempted to determine the specific and detailed N‐glycan profile for hepatocellular carcinoma (HCC) and investigate the prognostic capabilities.

Justin R. Henning, Christopher S. Graffeo, Adeel Rehman, Nina C. Fallon, Constantinos P. Zambirinis, Atsuo Ochi, Rocky Barilla, Mohsin Jamal, Michael Deutsch, Stephanie Greco, Melvin Ego‐Osuala, Usama Bin‐Saeed, Raghavendra S. Rao, Sana Badar, Juan P. Quesada, Devrim Acehan, George Miller – 15 January 2013 – Nonalcoholic steatohepatitis (NASH) is the most common etiology of chronic liver dysfunction in the United States and can progress to cirrhosis and liver failure. Inflammatory insult resulting from fatty infiltration of the liver is central to disease pathogenesis.