Sexual transmission of hepatitis C virus among monogamous heterosexual couples: The HCV partners study

Norah A. Terrault, Jennifer L. Dodge, Edward L. Murphy, John E. Tavis, Alexi Kiss, T. R. Levin, Robert G. Gish, Michael P. Busch, Arthur L. Reingold, Miriam J. Alter – 23 November 2012 – The efficiency of hepatitis C virus (HCV) transmission by sexual activity remains controversial. We conducted a cross‐sectional study of HCV‐positive subjects and their partners to estimate the risk for HCV infection among monogamous heterosexual couples. A total of 500 anti–HCV‐positive, human immunodeficiency virus–negative index subjects and their long‐term heterosexual partners were studied.

Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway

Lei Zhou, Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Jürgen Eckel, Zaiqing Yang – 23 November 2012 – Obesity is associated with many severe chronic diseases and deciphering its development and molecular mechanisms is necessary for promoting treatment.

Constitutive Notch2 signaling induces hepatic tumors in mice

Michael T. Dill, Luigi Tornillo, Thorsten Fritzius, Luigi Terracciano, David Semela, Bernhard Bettler, Markus H. Heim, Jan S. Tchorz – 23 November 2012 – Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC) are the most common liver tumors and a leading cause for cancer‐related death in men. Notch2 regulates cellular differentiation in the developing and adult liver.

Reducing the thickness of left lateral segment grafts in neonatal living donor liver transplantation

Mureo Kasahara, Seisuke Sakamoto, Takanobu Shigeta, Hajime Uchida, Ikumi Hamano, Hiroyuki Kanazawa, Megumi Kobayashi, Toshihiro Kitajima, Akinari Fukuda, Mohamed Rela – 21 November 2012 – Liver transplantation is now an established treatment for children with end‐stage liver disease. Left lateral segment (LLS) grafts are most commonly used in split and living donor liver transplantation in children. In very small children, LLS grafts can be too large, and further nonanatomical reduction has recently been introduced to mitigate the problem of large‐for‐size grafts.

Self‐Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

Jaana Helenius‐Hietala, Hellevi Ruokonen, Lisa Grönroos, Harri Rissanen, Liisa Suominen, Helena Isoniemi, Jukka H. Meurman – 21 November 2012 – Recipients of liver transplantation (LT) receive lifelong immunosuppression, which causes side effects. We investigated self‐reported oral symptoms and associated risk factors with the following hypothesis: symptoms and signs would differ between LT recipients of different etiology groups and also between LT recipients and a control population.

Influence of Age and Gender Before and After Liver Transplantation

Patrizia Burra, Eleonora De Martin, Stefano Gitto, Erica Villa – 21 November 2012 – Women constitute a particular group among patients with chronic liver disease and in the post–liver transplantation (LT) setting: they are set apart not only by traditional differences with respect to men (ie, body mass index, different etiologies of liver disease, and accessibility to transplantation) but also by factors related to hormonal changes that characterize first the fertile age and subsequently the postmenopausal period (eg, disease course variability and responses to therapy).

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