A simple strategy to identify acute hepatitis C virus infection among newly incarcerated injection drug users

Arthur Y. Kim, Ellen H. Nagami, Christopher E. Birch, Melinda J. Bowen, Georg M. Lauer, Barbara H. McGovern – 30 October 2012 – Acute hepatitis C virus (HCV) infection is underdiagnosed because most patients are asymptomatic. The majority of new infections occur among people who inject drugs (PWID), many of whom have a history of incarceration. In a previous pilot study, we identified symptomatic HCV cases, mainly among Caucasian inmates.

Hemorrhagic events in hepatocellular carcinoma patients treated with antiangiogenic therapies

Austin Duffy, Julia Wilkerson, Tim F. Greten – 30 October 2012 – The presence of cirrhosis increases the potential risk of hemorrhage for patients with hepatocellular carcinoma (HCC). We evaluated the relative risk for hemorrhage in patients with HCC treated with antiangiogenic agents. We performed a systematic review and meta‐analysis of antiangiogenic studies in HCC from 1995 to 2011. For nonrandomized studies we compared bleeding risk with other HCC single‐arm studies that did not include an antiangiogenic agent.

Low‐dose steroids associated with milder histological changes after pediatric liver transplantation

Silja Kosola, Hanna Lampela, Hannu Jalanko, Heikki Mäkisalo, Jouko Lohi, Johanna Arola, Mikko P. Pakarinen – 29 October 2012 – Controversy remains about the role of protocol liver biopsy for symptom‐free recipients and about the long‐term use of low‐dose steroids after pediatric liver transplantation (LT). We conducted a national cross‐sectional study of pediatric recipients who underwent LT between 1987 and 2007.

Center competition and outcomes following liver transplantation

Jeffrey B. Halldorson, Harry J. Paarsch, Jennifer L. Dodge, Alberto M. Segre, Jennifer Lai, John Paul Roberts – 19 October 2012 – In the United States, livers for transplantation are distributed within donation service areas (DSAs). In DSAs with multiple transplant centers, competition among centers for organs and recipients may affect recipient selection and outcomes in comparison with DSAs with only 1 center. The objective of this study was to determine whether competition within a DSA is associated with posttransplant outcomes and variations in patients wait‐listed within the DSA.

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