Catiane Tiecher Cusinato, Ana Paula Messa Koetz, Nêmora Tregnago Barcellos, Fernando Herz Wolff – 29 November 2012
Adriana Ordóñez, Erik L. Snapp, Lu Tan, Elena Miranda, Stefan J. Marciniak, David A. Lomas – 29 November 2012 – Point mutants of alpha1‐antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. These inclusions cause cell damage and predispose to ER stress in the absence of the classical unfolded protein response (UPR).
Zhiyong Du, Cuifeng Wei, Jiqi Yan, Baosan Han, Mingjun Zhang, Chenghong Peng, Yingbin Liu – 29 November 2012 – Mesenchymal stem cell (MSC) therapy can prevent hepatic parenchymal cell loss and promote tissue repair. However, poor MSC engraftment is one of the primary barriers to the effectiveness of cell therapy because culture‐expanded MSCs progressively down‐regulate C‐X‐C chemokine receptor type 4 (CXCR4) expression and lose their ability to migrate toward a concentration gradient of stromal cell–derived factor 1a (SDF1a).
Håkon Haugaa, Runar Almaas, Ebbe Billmann Thorgersen, Aksel Foss, Pål Dag Line, Truls Sanengen, Gísli Björn Bergmann, Per Ohlin, Lars Wælgaard, Guro Grindheim, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 29 November 2012 – Ischemic vascular complications and rejection occur more frequently with pediatric liver transplants versus adult liver transplants. Using intrahepatic microdialysis catheters, we measured lactate, pyruvate, glucose, and glycerol values at the bedside for a median of 10 days in 20 pediatric liver grafts.
Michael W. Fried, Donald M. Jensen – 29 November 2012
Matthew Zhang, Shinya Ueki, Shoko Kimura, Osamu Yoshida, Antonino Castellaneta, Kikumi S. Ozaki, Anthony J. Demetris, Mark Ross, Yoram Vodovotz, Angus W. Thomson, Donna B. Stolz, David A. Geller, Noriko Murase – 26 November 2012 – Dendritic cells (DCs) induce and regulate both innate and adaptive immune responses; however, their in vivo functional importance in hepatic ischemia/reperfusion (IR) injury is perplexing. We hypothesized that liver‐resident DC and locally recruited blood‐borne DC might have distinctive roles in hepatic IR injury.
Cindy Kunne, Alexandra Acco, Simon Hohenester, Suzanne Duijst, Dirk R. de Waart, Alaleh Zamanbin, Ronald P.J. Oude Elferink – 26 November 2012 – The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in a mouse model (Hrn mice) with hepatic disruption of the cytochrome p450 (CYP) oxidoreductase gene, encoding the single electron donor for all CYPs.
Richy C.Y. Chen, Phornnop Naiyanetr, Shang‐An Shu, Jinjun Wang, Guo‐Xiang Yang, Thomas P. Kenny, Kathryn C. Guggenheim, Jeffrey D. Butler, Christopher Bowlus, Mi‐Hua Tao, Mark J. Kurth, Aftab A. Ansari, Marshall Kaplan, Ross L. Coppel, Ana Lleo, M. Eric Gershwin, Patrick S.C. Leung – 26 November 2012 – Antimitochondrial antibodies (AMAs) directed against the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC‐E2) are detected in 95% of patients with primary biliary cirrhosis (PBC) and are present before the onset of clinical disease.
Vincenzo La Mura, Marcos Pasarín, Cintia Z. Meireles, Rosa Miquel, Aina Rodríguez‐Vilarrupla, Diana Hide, Jorge Gracia‐Sancho, Juan Carlos García‐Pagán, Jaime Bosch, Juan G. Abraldes – 26 November 2012 – Endothelial dysfunction drives vascular derangement and organ failure associated with sepsis. However, the consequences of sepsis on liver sinusoidal endothelial function are largely unknown. Statins might improve microvascular dysfunction in sepsis. The present study explores liver vascular abnormalities and the effects of statins in a rat model of endotoxemia.
Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hiromi Chikada, Ahn Dong Hyuck, Yuji Yamazaki, Eliane Wauthier, Hisao Tajiri, Lance D. Miller, Xin Wei Wang, Lola M. Reid, Hiromitsu Nakauchi – 23 November 2012 – Liver cancers, including hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCs), and fibrolamellar HCCs (FL‐HCCs) are among the most common cancers worldwide and are associated with a poor prognosis. Investigations of genes important in liver cancers have focused on Sal‐like protein 4 (SALL4), a member of a family of zinc finger transcription factors.