Risk factors for intrahepatic cholangiocarcinoma: Association between metformin use and reduced cancer risk

Roongruedee Chaiteerakij, Ju Dong Yang, William S. Harmsen, Seth W. Slettedahl, Teresa A. Mettler, Zachary S. Fredericksen, W. Ray Kim, Gregory J. Gores, Rosebud O. Roberts, Janet E. Olson, Terry M. Therneau, Lewis R. Roberts – 11 October 2012 – The associations between diabetes, smoking, obesity, and intrahepatic cholangiocarcinoma (ICC) risk remain inconclusive. Metformin is purportedly associated with a reduced risk for various cancers. This case‐control study evaluated risk factors for ICC and explored the effects of metformin on ICC risk in a clinic/hospital‐based cohort.

Importance of the temporary portocaval shunt during adult living donor liver transplantation

Santiago Sánchez‐Cabús, Constantino Fondevila, David Calatayud, Joana Ferrer, Pilar Taurá, José Fuster, Juan Carlos García‐Valdecasas – 11 October 2012 – Adult living donor liver transplantation (aLDLT) is associated with surgical risks for the donor and with the possibility of small‐for‐size syndrome (SFSS) for the recipient, with both events being of great importance.

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

Lixin Zhu, Susan S. Baker, Chelsea Gill, Wensheng Liu, Razan Alkhouri, Robert D. Baker, Steven R. Gill – 11 October 2012 – Nonalcoholic steatohepatitis (NASH) is a serious liver disease associated with obesity. Characterized by metabolic syndrome, hepatic steatosis, and liver inflammation, NASH is believed to be under the influence of the gut microflora. Here, the composition of gut bacterial communities of NASH, obese, and healthy children was determined by 16S ribosomal RNA pyrosequencing.

Anomalous hepatic vein anatomy of left lateral section grafts and customized unification venoplasty for pediatric living donor liver transplantation

Shin Hwang, Ki‐Hun Kim, Dae‐Yeon Kim, Kyoung‐Mo Kim, Chul‐Soo Ahn, Deok‐Bog Moon, Tae‐Yong Ha, Gi‐Won Song, Dong‐Hwan Jung, Jung‐Man Namgoong, Gil‐Chun Park, David C. Cronin, Sung‐Gyu Lee – 8 October 2012 – In liver transplantation, a left lateral section (LLS) graft may have an unusual variant left hepatic vein (LHV) anatomy. This study was designed to analyze the incidence of unusual LHV variants and to determine technical methods for effective reconstruction in infant recipients weighing approximately 10 kg or less.

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