Therapeutic advantage of anti‐VAP‐1 over anti‐α4 integrin antibody in concanavalin a‐induced hepatitis

Woo‐Yong Lee, Marko Salmi, Margaret M. Kelly, Sirpa Jalkanen, Paul Kubes – 17 May 2013 – Hepatitis induced by concanavalin A (Con A) in mice is well known to be a T‐lymphocyte‐mediated injury. It has been reported that T helper (Th)1 and Th2 lymphocytes use α4 integrin and vascular adhesion protein (VAP)−1, respectively, to adhere within the hepatic sinusoids. Therefore, we investigated whether inhibition of these molecules ameliorates or worsens the Con A‐induced hepatic injury in vivo.

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