Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon‐induced hepatitis B e antigen seroconversion

Hung‐Chih Yang, Chi‐Ling Chen, Yueh‐Chi Shen, Cheng‐Yuan Peng, Chun‐Jen Liu, Tai‐Chung Tseng, Tung‐Hung Su, Wan‐Long Chuang, Ming‐Lung Yu, Chia‐Yen Dai, Chen‐Hua Liu, Pei‐Jer Chen, Ding‐Shinn Chen, Jia‐Horng Kao – 30 October 2012 – Precore (PC) (G1896A) and basal core promoter (BCP) (A1762T/G1764A) mutations of the hepatitis B virus (HBV) genome often emerge in chronic hepatitis B (CHB) patients. Their roles in hepatitis B e antigen (HBeAg) seroconversion induced by interferon (IFN) therapy remain controversial, partly because quantitative analysis for these mutants is lacking.

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