Retracted: Equilibrative nucleoside transporter (ENT)‐1‐dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion

Michael A. Zimmerman, Eunyoung Tak, Stefan F. Ehrentraut, Maria Kaplan, Antasia Giebler, Tingting Weng, Doo‐Sup Choi, Michael R. Blackburn, Igal Kam, Holger K. Eltzschig, Almut Grenz – 23 May 2013 – Ischemia and reperfusion‐elicited tissue injury contributes to morbidity and mortality of hepatic surgery and during liver transplantation. Previous studies implicated extracellular adenosine signaling in liver protection.

Cross‐talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

Guanhua Xie, Gamze Karaca, Marzena Swiderska‐Syn, Gregory A. Michelotti, Leandi Krüger, Yuping Chen, Richard T. Premont, Steve S. Choi, Anna Mae Diehl – 23 May 2013 – Liver repair involves phenotypic changes in hepatic stellate cells (HSCs) and reactivation of morphogenic signaling pathways that modulate epithelial‐to‐mesenchymal/mesenchymal‐to‐epithelial transitions, such as Notch and Hedgehog (Hh). Hh stimulates HSCs to become myofibroblasts (MFs).

Activator protein 1 transcription factor fos‐related antigen 1 (fra‐1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism

Sebastian C. Hasenfuss, Latifa Bakiri, Martin K. Thomsen, Rainer Hamacher, Erwin F. Wagner – 23 May 2013 – The Activator Protein 1 (AP‐1) transcription factor subunit Fos‐related antigen 1 (Fra‐1) has been implicated in liver fibrosis. Here we used loss‐of‐function as well as switchable, cell type‐specific, gain‐of‐function alleles for Fra‐1 to investigate the relevance of Fra‐1 expression in cholestatic liver injury and fibrosis. Our results indicate that Fra‐1 is dispensable in three well‐established, complementary models of liver fibrosis.

Epigenetic regulation of MicroRNA‐122 by peroxisome proliferator activated receptor‐gamma and hepatitis b virus X protein in hepatocellular carcinoma cells

Kyoungsub Song, Chang Han, Jinqiang Zhang, Dongdong Lu, Srikanta Dash, Mark Feitelson, Kyu Lim, Tong Wu – 23 May 2013 – MicroRNA‐122 (miR‐122), a pivotal liver‐specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR‐122 in human HCC cells and to examine the effect of hepatitis C virus (HCV) and hepatitis B virus (HBV).

Extrahepatic Anomalies in Infants With Biliary Atresia: Results of a Large Prospective North American Multicenter Study

Kathleen B. Schwarz, Barbara H. Haber, Philip Rosenthal, Cara L. Mack, Jeffrey Moore, Kevin Bove, Jorge A. Bezerra, Saul J. Karpen, Nanda Kerkar, Benjamin L. Shneider, Yumirle P. Turmelle, Peter F. Whitington, Jean P. Molleston, Karen F. Murray, Vicky L. Ng, René Romero, Kasper S. Wang, Ronald J. Sokol, John C. Magee, Childhood Liver Disease Research and Education Network – 23 May 2013 – The etiology of biliary atresia (BA) is unknown.

Terutroban, a TP‐receptor antagonist, reduces portal pressure in cirrhotic rats

Eugenio Rosado, Aina Rodríguez‐Vilarrupla, Jorge Gracia‐Sancho, Dinesh Tripathi, Héctor García‐Calderó, Jaume Bosch, Juan Carlos García‐Pagán – 23 May 2013 – Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane‐A2/prostaglandin‐endoperoxide (TP) receptor.

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