Performance of chronic kidney disease epidemiology collaboration creatinine‐cystatin C equation for estimating kidney function in cirrhosis

Ayse L. Mindikoglu, Thomas C. Dowling, Matthew R. Weir, Stephen L. Seliger, Robert H. Christenson, Laurence S. Magder – 6 June 2013 – Conventional creatinine‐based glomerular filtration rate (GFR) equations are insufficiently accurate for estimating GFR in cirrhosis. The Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) recently proposed an equation to estimate GFR in subjects without cirrhosis using both serum creatinine and cystatin C levels.

Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion

Jie Xia, Yongjie Zhou, Hongjie Ji, Yujia Wang, Qiong Wu, Ji Bao, Feng Ye, Yujun Shi, Hong Bu – 6 June 2013 – Histone deacetylases 1 and 2 (HDAC1 and HDAC2) are ubiquitously expressed in tissues, including the liver, and play critical roles in numerous physiopathological processes. Little is known regarding the role of HDAC1 and HDAC2 in liver regeneration.

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice

Anup Ramachandran, Mitchell R. McGill, Yuchao Xie, Hong‐Min Ni, Wen‐Xing Ding, Hartmut Jaeschke – 6 June 2013 – Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the U.S., but the pathophysiology is incompletely understood. Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered necrotic in mice and in humans. Recent findings suggest that the receptor interacting protein kinase 3 (RIP3) acts as a switch from apoptosis to necrosis (programmed necrosis).

Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis

Justin M. Nussbaum, Liuhong J. Liu, Syeda A. Hasan, Madeline Schaub, Allyson McClendon, Didier Y.R. Stainier, Takuya F. Sakaguchi – 6 June 2013 – Nonalcoholic fatty liver disease is the most common liver disease in both adults and children. The earliest stage of this disease is hepatic steatosis, in which triglycerides are deposited as cytoplasmic lipid droplets in hepatocytes. Through a forward genetic approach in zebrafish, we found that guanosine monophosphate (GMP) synthetase mutant larvae develop hepatic steatosis.

Off‐therapy durability of response to entecavir therapy in hepatitis B e antigen‐negative chronic hepatitis B patients

Wen‐Juei Jeng, I‐Shyan Sheen, Yi‐Cheng Chen, Chao‐Wei Hsu, Rong‐Nan Chien, Chia‐Ming Chu, Yun‐Fan Liaw – 6 June 2013 – The optimal duration of nucelos(t)ide analog (Nuc) treatment in hepatitis B e antigen (HBeAg)‐negative patients with chronic hepatitis B virus (HBV) infection is unknown. The Asian Pacific Association for the Study of the Liver (APASL) guidelines recommend that treatment can be discontinued if undetectable HBV‐DNA has been documented on three occasions ≥6 months apart.

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