Yanjun Jiang, Polina Iakova, Jingling Jin, Emily Sullivan, Vladislav Sharin, Il‐Hwa Hong, Sayee Anakk, Angela Mayor, Gretchen Darlington, Milton Finegold, David Moore, Nikolai A. Timchenko – 21 November 2012 – One of the early events in the development of liver cancer is a neutralization of tumor suppressor proteins Rb, p53, hepatocyte nuclear factor 4α (HNF4α), and CCAAT/enhancer binding protein (C/EBP) α. The elimination of these proteins is mediated by a small subunit of proteasome, gankyrin, which is activated by cancer.

Utaroh Motosugi, Tomoaki Ichikawa, Tsutomu Araki, Masanori Matsuda, Hideki Fujii, Nobuyuki Enomoto – 21 November 2012

Mona El Khatib, Anna Kalnytska, Vindhya Palagani, Uta Kossatz, Michael P. Manns, Nisar P. Malek, Ludwig Wilkens, Ruben R. Plentz – 21 November 2012 – The Hedgehog signaling pathway plays a pivotal role during embryonic development, stem cell maintenance, and wound healing. Hedgehog signaling also is deregulated in many cancers. However, the role of this signaling pathway in the carcinogenesis of cholangiocarcinoma (CCC) is still unknown.

Dominik Bettinger, Michael Schultheiss, Nadine Hennecke, Elisabeth Panther, Eva Knüppel, Hubert E. Blum, Robert Thimme, Hans Christian Spangenberg – 21 November 2012

Jacob Aubuchon, Erin Maynard, Anand Lakshminarasimhachar, William Chapman, Ivan Kangrga – 21 November 2012

Yee Lee Cheah, Mary Ann Simpson, James J. Pomposelli, Elizabeth A. Pomfret – 21 November 2012 – The incidence of morbidity and mortality after living donor liver transplantation (LDLT) is not well understood because reporting is not standardized and relies on single‐center reports. Aborted hepatectomies (AHs) and potentially life‐threatening near‐miss events (during which a donor's life may be in danger but after which there are no long‐term sequelae) are rarely reported. We conducted a worldwide survey of programs performing LDLT to determine the incidence of these events.

Gang Zheng, Long Jiang Zhang, Yue Cao, Guang Ming Lu – 21 November 2012

Tatyana V. Masyuk, Brynn N. Radtke, Angela J. Stroope, Jesús M. Banales, Sergio A. Gradilone, Bing Huang, Anatoliy I. Masyuk, Marie C. Hogan, Vicente E. Torres, Nicholas F. LaRusso – 21 November 2012 – In polycystic liver (PLD) and kidney (PKD) diseases, increased cyclic adenosine monophosphate (cAMP) levels trigger hepatorenal cystogenesis. A reduction of the elevated cAMP by targeting somatostatin receptors (SSTRs) with octreotide (OCT; a somatostatin analog that preferentially binds to SSTR2) inhibits cyst growth.

Emre Turer, Don C. Rockey, Amit G. Singal – 21 November 2012

Khayriyyah Mohd Hanafiah, Justina Groeger, Abraham D. Flaxman, Steven T. Wiersma – 21 November 2012 – In efforts to inform public health decision makers, the Global Burden of Diseases, Injuries, and Risk Factors 2010 (GBD2010) Study aims to estimate the burden of disease using available parameters. This study was conducted to collect and analyze available prevalence data to be used for estimating the hepatitis C virus (HCV) burden of disease.