Anup Ramachandran, Mitchell R. McGill, Yuchao Xie, Hong‐Min Ni, Wen‐Xing Ding, Hartmut Jaeschke – 6 June 2013 – Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the U.S., but the pathophysiology is incompletely understood. Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered necrotic in mice and in humans. Recent findings suggest that the receptor interacting protein kinase 3 (RIP3) acts as a switch from apoptosis to necrosis (programmed necrosis).

Scott B. Reeder – 6 June 2013

Justin M. Nussbaum, Liuhong J. Liu, Syeda A. Hasan, Madeline Schaub, Allyson McClendon, Didier Y.R. Stainier, Takuya F. Sakaguchi – 6 June 2013 – Nonalcoholic fatty liver disease is the most common liver disease in both adults and children. The earliest stage of this disease is hepatic steatosis, in which triglycerides are deposited as cytoplasmic lipid droplets in hepatocytes. Through a forward genetic approach in zebrafish, we found that guanosine monophosphate (GMP) synthetase mutant larvae develop hepatic steatosis.

Abhijeet Waghray, Robert O'Shea, Rish Pai, K.V. Narayanan Menon – 6 June 2013

Wen‐Juei Jeng, I‐Shyan Sheen, Yi‐Cheng Chen, Chao‐Wei Hsu, Rong‐Nan Chien, Chia‐Ming Chu, Yun‐Fan Liaw – 6 June 2013 – The optimal duration of nucelos(t)ide analog (Nuc) treatment in hepatitis B e antigen (HBeAg)‐negative patients with chronic hepatitis B virus (HBV) infection is unknown. The Asian Pacific Association for the Study of the Liver (APASL) guidelines recommend that treatment can be discontinued if undetectable HBV‐DNA has been documented on three occasions ≥6 months apart.

Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco – 6 June 2013 – Genetically determined loss of fibrocystin function causes congenital hepatic fibrosis (CHF), Caroli disease (CD), and autosomal recessive polycystic kidney disease (ARPKD). Cystic dysplasia of the intrahepatic bile ducts and progressive portal fibrosis characterize liver pathology in CHF/CD.

Sara Montagnese, Cristiano De Pittà, Michele De Rui, Michela Corrias, Matteo Turco, Carlo Merkel, Piero Amodio, Rodolfo Costa, Debra J. Skene, Angelo Gatta – 6 June 2013 – A considerable proportion of patients with cirrhosis exhibit insomnia, delayed sleep habits, and excessive daytime sleepiness. These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic. Sleep is regulated by the interaction of a homeostatic and a circadian process.

Víctor Díaz, Elena Gammella, Stefania Recalcati, Paolo Santambrogio, Arianne Monge Naldi, Johannes Vogel, Max Gassmann, Gaetano Cairo – 6 June 2013 – The liver‐derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. The regulation of hepcidin, however, is not completely understood and includes a variety of different signals.

Drew Feranchak – 6 June 2013

Yoshikuni Kawaguchi, Yasuhiko Sugawara, Takeaki Ishizawa, Shouichi Satou, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo – 3 June 2013