Adriana Ordóñez, Erik L. Snapp, Lu Tan, Elena Miranda, Stefan J. Marciniak, David A. Lomas – 29 November 2012 – Point mutants of alpha1‐antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. These inclusions cause cell damage and predispose to ER stress in the absence of the classical unfolded protein response (UPR).

Catiane Tiecher Cusinato, Ana Paula Messa Koetz, Nêmora Tregnago Barcellos, Fernando Herz Wolff – 29 November 2012

Katharine Secunda, Elisa J. Gordon, Min W. Sohn, Laura A. Shinkunas, Lauris C. Kaldjian, Michael D. Voigt, Josh Levitsky – 29 November 2012 – Candidate selection for liver transplantation presents challenging ethical issues that require balancing the principles of justice and utility. The goal of this study was to assess the opinions of US transplant providers regarding the ways in which controversial medical and psychosocial characteristics influence patient eligibility for liver transplantation.

Marina Berenguer, Geoffrey McCaughan – 29 November 2012

Thomas Mone, John Heldens, Claus U. Niemann – 29 November 2012

Kenichi Harada, Junko Hirohara, Yoshiyuki Ueno, Toshiaki Nakano, Yuko Kakuda, Hirohito Tsubouchi, Takafumi Ichida, Yasuni Nakanuma – 29 November 2012 – Primary biliary cirrhosis (PBC) primarily affects females and is rarely complicated by hepatocellular carcinoma (HCC). Although the HCC incidence in PBC patients is low, several characteristics and risk factors associated with its development have been reported. In this study, national data concerning the current status of carcinogenesis in PBC patients in Japan are reviewed.

George N. Ioannou, Christopher L. Bryson, Noel S. Weiss, John D. Scott, Edward J. Boyko – 29 November 2012

Jay H. Hoofnagle, Jose Serrano, James E. Knoben, Victor J. Navarro – 29 November 2012

Ana M. Tormos, Alessandro Arduini, Raquel Talens‐Visconti, Ivan del Barco Barrantes, Angel R. Nebreda, Juan Sastre – 29 November 2012 – p38α mitogen‐activated protein kinases (MAPK) may be essential in the up‐regulation of proinflammatory cytokines and can be activated by transforming growth factor β, tumor necrosis factor‐α, interleukin‐1β, and oxidative stress. p38 MAPK activation results in hepatocyte growth arrest, whereas increased proliferation has been considered a hallmark of p38α‐deficient cells.

Tsan‐Shiun Lin, Chao‐Long Chen, Allan M. Concejero, Anthony Q. Yap, Yu‐Hung Lin, Chun‐Yi Liu, Yuan‐Cheng Chiang, Chih‐Chi Wang, Shih‐Ho Wang, Chih‐Che Lin, Chee‐Chien Yong, Yu‐Fan Cheng – 29 November 2012 – We describe our early and long‐term experience with routine biliary reconstruction via a microsurgical technique in living donor liver transplantation (LDLT). One hundred seventy‐seven grafts (including 3 dual grafts) were primarily transplanted into 174 recipients. The minimum follow‐up was 44 months.