Human blood dendritic cell antigen 3 (BDCA3)+ dendritic cells are a potent producer of interferon‐λ in response to hepatitis C virus

Sachiyo Yoshio, Tatsuya Kanto, Shoko Kuroda, Tokuhiro Matsubara, Koyo Higashitani, Naruyasu Kakita, Hisashi Ishida, Naoki Hiramatsu, Hiroaki Nagano, Masaya Sugiyama, Kazumoto Murata, Takasuke Fukuhara, Yoshiharu Matsuura, Norio Hayashi, Masashi Mizokami, Tetsuo Takehara – 5 December 2012 – The polymorphisms in the interleukin (IL)‐28B (interferon‐lambda [IFN]‐λ3) gene are strongly associated with the efficacy of hepatitis C virus (HCV) clearance.

Characterization of the inhibition of hepatitis C virus entry by In vitro–generated and patient‐derived oxidized low‐density lipoprotein

Sandra Westhaus, Dorothea Bankwitz, Stefanie Ernst, Katrin Rohrmann, Ilka Wappler, Clemens Agné, Maren Luchtefeld, Bernhard Schieffer, Christoph Sarrazin, Michael P. Manns, Thomas Pietschmann, Sandra Ciesek, Thomas von Hahn – 5 December 2012 – Oxidized low‐density lipoprotein (oxLDL) has been reported as an inhibitor of hepatitis C virus (HCV) cell entry, making it the only known component of human lipid metabolism with an antiviral effect on HCV.

Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon‐based antiviral therapy

Davide Bitetto, Nadia Bortolotti, Edmondo Falleti, Sara Vescovo, Carlo Fabris, Giovanna Fattovich, Annarosa Cussigh, Sara Cmet, Ezio Fornasiere, Elisa Ceriani, Mario Pirisi, Pierluigi Toniutto – 5 December 2012 – Recent data suggest that vitamin A modulates the expression of type I interferon receptor enhancing the antireplication effect of interferon‐α on hepatitis C virus (HCV).

Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5‐year prospective cohort study

Sung Keun Park, Mi Hae Seo, Ho Cheol Shin, Jae‐Hong Ryoo – 5 December 2012 – There have been several reports about the clinical association between type 2 diabetes mellitus (DM) and nonalcoholic fatty liver disease (NAFLD). However, most of the studies were about the unilateral effects of type 2 DM on NAFLD, and studies on the reverse relation are rare. Thus, this study was designed to investigate the effect of NAFLD on type 2 DM. We conducted a prospective cohort study on 25,232 Korean men without type 2 DM for 5 years.

Association between liver‐specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease

Leon A. Adams, Scott W. White, Julie A. Marsh, Stephen J. Lye, Kristin L. Connor, Richard Maganga, Oyekoya T. Ayonrinde, John K. Olynyk, Trevor A. Mori, Lawrence J. Beilin, Lyle J. Palmer, Jeffrey M. Hamdorf, Craig E. Pennell – 5 December 2012 – Genetic factors account for a significant proportion of the phenotypic variance of nonalcoholic fatty liver disease (NAFLD); however, very few predisposing genes have been identified.

Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the milan criteria in transplantable hepatocellular carcinoma: A retrospective analysis based on tissue microarrays

Ju Hyun Shim, Han Chu Lee, Seungbong Han, Hyo Jeong Kang, Eunsil Yu, Sung‐Gyu Lee – 2 December 2012 – We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. The expression of alpha‐fetoprotein (AFP), HNF1α, and HNF1β was examined with immunohistochemistry on duplicate tissue microarray slides containing HCC tumor explants.

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