William R. Proctor, Mala Chakraborty, Lynette S. Chea, Jeffrey C. Morrison, Julia D. Berkson, Kenrick Semple, Mohammed Bourdi, Lance R. Pohl – 12 December 2012 – Drug‐induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease. This is due in part to the lack of animal models and knowledge of susceptibility factors that predispose individuals to DILI. In this regard, liver eosinophilia has often been associated with DILI, although its role remains unclear.

Brian R. Edlin – 12 December 2012 – Hepatitis C is the most prevalent bloodborne viral disease in the United States and the deadliest. This year, the U.S. Preventive Services Task Force (USPSTF) will update its 2004 hepatitis C guideline, which recommends against screening asymptomatic adults for hepatitis C. This guideline has hampered public health efforts to encourage screening and identify and refer infected persons for care by declaring that such interventions were not supported by the evidence.

Jin‐feng Huang, Ying‐jun Guo, Chen‐xi Zhao, Sheng‐xian Yuan, Yue Wang, Guan‐nan Tang, Wei‐ping Zhou, Shu‐han Sun – 12 December 2012 – The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long noncoding RNAs (lncRNAs), which regulate gene expression with little or no protein‐coding capacity, are involved in diverse biological processes and in carcinogenesis.

Cleide G. da Silva, Peter Studer, Marco Skroch, Jerome Mahiou, Darlan C. Minussi, Clayton R. Peterson, Suzhuei W. Wilson, Virendra I. Patel, Averil Ma, Eva Csizmadia, Christiane Ferran – 12 December 2012 – Liver regeneration is of major clinical importance in the setting of liver injury, resection, and transplantation. A20, a potent antiinflammatory and nuclear factor kappa B (NF‐κB) inhibitory protein, has established pro‐proliferative properties in hepatocytes, in part through decreasing expression of the cyclin dependent kinase inhibitor, p21.

Safa Al‐Shamma, Balint Eross, Simon Mclaughlin – 12 December 2012

Brian R. Edlin – 12 December 2012 – Hepatitis C is the most prevalent bloodborne viral disease in the United States and the deadliest. This year, the U.S. Preventive Services Task Force (USPSTF) will update its 2004 hepatitis C guideline, which recommends against screening asymptomatic adults for hepatitis C. This guideline has hampered public health efforts to encourage screening and identify and refer infected persons for care by declaring that such interventions were not supported by the evidence.

Safa Al‐Shamma, Balint Eross, Simon Mclaughlin – 12 December 2012

Josh Levitsky, Gabriel C. Oniscu – 12 December 2012 – From May 16–19, 2012, the International Liver Transplantation Society held its annual congress in San Francisco, CA. More than 1300 registrants attended the meeting, which included a premeeting conference entitled Balancing Risk in Liver Transplantation, focused topic sessions, and a variety of oral and poster presentations. This report is not all‐inclusive and focuses on specific research abstracts on key topics in liver transplantation.

Paolo Simone, Faouzi Saliba, Lutz Fischer – 10 December 2012

Belen Gil‐Alzugaray, Ana Chopitea, Mercedes Iñarrairaegui, Jose I. Bilbao, Macarena Rodriguez‐Fraile, Javier Rodriguez, Alberto Benito, Inés Dominguez, Delia D'Avola, Jose I. Herrero, Jorge Quiroga, Jesus Prieto, Bruno Sangro – 10 December 2012 – Radioembolization (RE)‐induced liver disease (REILD) has been defined as jaundice and ascites appearing 1 to 2 months after RE in the absence of tumor progression or bile duct occlusion.