Xiao‐Yong Huang, Ai‐Wu Ke, Guo‐Ming Shi, Xin Zhang, Chi Zhang, Ying‐Hong Shi, Xiao‐Ying Wang, Zhen‐Bin Ding, Yong‐Sheng Xiao, Jun Yan, Shuang‐Jian Qiu, Jia Fan, Jian Zhou – 12 January 2013 – The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular pathogenesis remains incompletely defined in HCC. Here we report that increased expression of αB‐Crystallin in human HCC predicts poor survival and disease recurrence after surgery.

David Fuks, Francois Durand, Jacques Belghiti – 12 January 2013

Simon Hohenester, Ulrich Beuers, Juan F. Medina, Ronald P. Oude Elferink – 12 January 2013

M. Eric Gershwin, Patrick S.C. Leung, William M. Ridgway, Ross L. Coppel, Aftab A. Ansari – 12 January 2013

Wolfgang Sieghart, Florian Hucke, Matthias Pinter, Ivo Graziadei, Wolfgang Vogel, Christian Müller, Harald Heinzl, Michael Trauner, Markus Peck‐Radosavljevic – 12 January 2013 – We aimed to establish an objective point score to guide the decision for retreatment with transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).

Angelina Mouralidarane, Junpei Soeda, Clara Visconti‐Pugmire, Anne‐Maj Samuelsson, Joaquim Pombo, Xanthi Maragkoudaki, Adil Butt, Ruma Saraswati, Marco Novelli, Guiseppe Fusai, Lucilla Poston, Paul D. Taylor, Jude A. Oben – 12 January 2013 – The global prevalence of obesity‐induced liver disease (nonalcoholic fatty liver disease; NAFLD) is rising. Suggested causes include a role for in utero influences of maternal obesity compounded by the availability of energy‐dense foods throughout postnatal life.

Chad Walesky, Genea Edwards, Prachi Borude, Sumedha Gunewardena, Maura O'Neil, Byunggil Yoo, Udayan Apte – 12 January 2013 – Hepatocyte nuclear factor 4 alpha (HNF4α), the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation by way of unknown mechanisms. We investigated the mechanisms of HNF4α‐induced inhibition of hepatocyte proliferation using a novel tamoxifen (TAM)‐inducible, hepatocyte‐specific HNF4α knockdown mouse model.

Christopher E. McGowan, Ali Monis, Bruce R. Bacon, Josep Mallolas, Fernando L. Goncales, Ioannis Goulis, Fred Poordad, Nezam Afdhal, Stefan Zeuzem, Teerha Piratvisuth, Patrick Marcellin, Michael W. Fried – 12 January 2013 – Chronic infection with the hepatitis C virus (HCV) is a leading cause of global morbidity and mortality. Although recent advances in antiviral therapy have led to significant improvements in treatment response rates, only a minority of infected patients are treated. Multiple barriers may impede the delivery of HCV therapy.

Alina Pascale, Olivier Chazouillères, Lawrence Serfaty – 12 January 2013

Xin‐Long Yan, Ya‐Li Jia, Lin Chen, Quan Zeng, Jun‐Nian Zhou, Chun‐Jiang Fu, Hai‐Xu Chen, Hong‐Feng Yuan, Zhi‐Wei Li, Lei Shi, Ying‐Chen Xu, Jing‐Xue Wang, Xiao‐Mei Zhang, Li‐Juan He, Chao Zhai, Wen Yue, Xue‐Tao Pei – 12 January 2013 – Cancer‐associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer‐associated MSCs (LC‐MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified the presence of MSCs in HCC tissues.