Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes

Michele A. Rodrigues, Dawidson A. Gomes, Romina Fiorotto, Mateus T. Guerra, Jittima Weerachayaphorn, Tao Bo, William C. Sessa, Mario Strazzabosco, Michael H. Nathanson – 18 July 2022 – Fluid and bicarbonate secretion is a principal function of cholangiocytes, and impaired secretion results in cholestasis. Cholangiocyte secretion depends on peri‐apical expression of the type 3 inositol trisphosphate receptor (ITPR3), and loss of this intracellular Ca2+ release channel is a final common event in most cholangiopathies.

Hugo Ramon Rosen, MD, FAASLD

deceased member

Hugo Ramon Rosen, MD, FAASLD

The American Association for the Study of Liver Diseases (AASLD) acknowledges the passing of Hugo Ramon Rosen, MD, FAASLD. Dr. Rosen passed away December 28, 2021.

He was a prolific physician-scientist and liver immunologist with important contributions to the field of Hepatitis C Research. He served on the board of directors of the American Society of Transplantation and was honored with the American Society of Transplantation Achievement in Clinical Science Award. He received his M.D. at the University of Miami and completed residency at Beth Israel-Deaconess Hospital and Harvard Medical School, and a fellowship in gastroenterology and hepatology at the University of California Los Angeles. He was a principal investigator on several National Institutes of Health studies focusing on the Hepatitis C virus. Dr. Rosen was a Division Chief of Gastroenterology and Hepatology at the University of Colorado, Boulder and was recruited to become the Chairman of the Department of Medicine at Keck School of Medicine at the University of Sothern California.

Dr. Rosen was a beloved member of the liver community and will be remembered for his dedication and passion to the study of liver disease. He joined AASLD in 1992 and was an active member and fellow at the time of his passing. Dr. Rosen’s obituary as well as the USC Hugo Rosen MD Legacy Fund which was created to memorialize Hugo's greatest passion and professional mission: to mentor and support young, underrepresented scientific investigators, can be found here.

Black patients and women have reduced access to liver transplantation for alcohol‐associated liver disease

Alyson Kaplan, Nabeel Wahid, Brett E. Fortune, Elizabeth Verna, Karim Halazun, Benjamin Samstein, Robert S. Brown, Russell Rosenblatt – 17 July 2022 – Although sex and racial disparities for liver transplantation (LT) are known, it is unclear if disparities exist for patients with alcohol‐associated liver disease (ALD). We aimed to compare sex and racial/ethnic differences in mortality, LT listing, and LT rates in patients with and without ALD.

Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on Alcohol Abuse and Alcoholism murine model of chronic and binge ethanol feeding

Mallika Mathur, Yu‐Te Yeh, Rakesh K. Arya, Long Jiang, Majid Pornour, Weiping Chen, Yinyan Ma, Bin Gao, Ling He, Zhekang Ying, Bingzhong Xue, Hang Shi, Youngshim Choi, Liqing Yu – 17 July 2022

Standardized upfront Glissonean approach and liver hanging maneuver reduces bile leakage from the hepatic hilum in living donors

Kazuya Hirukawa, Yuki Masuda, Yuta Abe, Hiroshi Yagi, Sho Ibuki, Osamu Itano, Masahiro Shinoda, Minoru Kitago, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Yutaka Nakano, Kentaro Matsubara, Hideaki Obara, Yohei Yamada, Tatsuo Kuroda, Taizo Hibi, Yuko Kitagawa – 17 July 2022 – Biliary complications after hepatectomy in living donors have yet to be eradicated.

Substance‐use simulation impairs driving capability in patients with cirrhosis regardless of hepatic encephalopathy

Chathur Acharya, Sara McGeorge, Andrew Fagan, James B. Wade, Hannah Lee, Velimir Luketic, Richard K. Sterling, Leroy Thacker, Jasmohan S. Bajaj – 16 July 2022 – Driving is independently affected by cirrhosis and hepatic encephalopathy (HE) and alcohol/substance use, but their concomitant impact is unclear. We aimed to determine the impact of alcohol and other substances on driving‐simulator performance in cirrhosis with and without HE.

Use and outcomes of hepatitis B virus–positive grafts in orthotopic liver transplantation in the United States from 1999 to 2021

Saad Emhmed Ali, Philip Vutien, C. Andrew Bonham, Charles Landis, Paul Kwo, Carlos Esquivel, Mindie H. Nguyen – 16 July 2022 – The demand for orthotopic liver transplantation (OLT) is projected to increase, which indicates a need to expand the liver donor pool. We aimed to investigate the use of hepatitis B virus (HBV)–positive grafts and the outcomes of recipients undergoing OLT with HBV‐positive grafts.

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