Activin B promotes the initiation and progression of liver fibrosis

Yan Wang, Matthew Hamang, Alexander Culver, Huaizhou Jiang, Jennifer Yanum, Veronica Garcia, Joonyong Lee, Emily White, Praveen Kusumanchi, Naga Chalasani, Suthat Liangpunsakul, Benjamin C. Yaden, Guoli Dai – 21 July 2022 – The role of activin B, a transforming growth factor β (TGFβ) superfamily cytokine, in liver health and disease is largely unknown. We aimed to investigate whether activin B modulates liver fibrogenesis.

Impact of COVID‐19 pandemic on HCV care cascade in Rwanda: Ecological study from July 2019 to June 2021

Jean Damascene Makuza, Dahn Jeong, Phyumar Soe, Sofia Bartlett, Héctor A. Velásquez García, Mawuena Binka, Prince Adu, Donatha Dushimiyimana, Valentine Dushimiyimana, Clarisse Maliza, Marie Paul Nisingizwe, Gallican Rwibasira, Albert Tuyishime, Naveed Z. Janjua – 21 July 2022

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee – 21 July 2022 – Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficiency.

Rhesus rotavirus receptor‐binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia

Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Sarah Mowery, Holly M. Poling, Jaroslaw Meller, Astha Malik, Monica McNeal, Greg Tiao – 21 July 2022 – Biliary atresia (BA) is a neonatal inflammatory cholangiopathy that requires surgical intervention by Kasai portoenterostomy to restore biliary drainage. Even with successful portoenterostomy, most patients diagnosed with BA progress to end‐stage liver disease, necessitating a liver transplantation for survival.

Subscribe to