Nam‐Joon Yi, Kyung‐Suk Suh, Jai Young Cho, Hae Won Lee, Eung‐Ho Cho, Sung Hoon Yang, Yong Beom Cho, Kuhn Uk Lee – 30 May 2007 – A donor right hepatectomy (RH) is associated with a higher rate of morbidity than a left hepatectomy. Therefore, the precise morbidity should be known to improve the success of donor RH implementation. However, the rate of complication varies according to the individual definition of morbidity.

Masahiko Taniguchi, Tsuyoshi Shimamura, Tomomi Suzuki, Kenichiro Yamashita, Tetsu Oura, Masaaki Watanabe, Toshiya Kamiyama, Michiaki Matsushita, Hiroyuki Furukawa, Satoru Todo – 30 May 2007

Takuya Hashimoto, Yasuhiko Sugawara, Masatoshi Makuuchi – 30 May 2007

Hartmut Jaeschke, Jie Liu – 30 May 2007

Tung‐Hung Su, Jia‐Horng Kao, Ding‐Shinn Chen – 30 May 2007

Zhongjun Dong, Jianhong Zhang, Rui Sun, Haiming Wei, Zhigang Tian – 29 May 2007 – A fraction of HBV carriers have a risk to develop liver cancer. Because liver possesses a strong regeneration capability, surgical resection of cancerous liver or transplantation with healthy liver is an alternate choice for HBV‐caused hepatocarcinoma therapy. How HBV infection affects the regeneration of hepatectomized or transplanted liver remains elusive. We report that partial hepatectomy (PHx)‐induced liver regeneration was reduced in HBV transgenic (HBV‐tg) mice, a model of human HBV infection.

Gavin Wright, Nathan A. Davies, Debbie L. Shawcross, Stephen J. Hodges, Claudia Zwingmann, Heather F. Brooks, Ali R. Mani, David Harry, Vanessa Stadlbauer, Zheng Zou, Roger Williams, Ceri Davies, Kevin P. Moore, Rajiv Jalan – 29 May 2007 – This study explores the hypothesis that the inflammatory response induced by administration of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this is associated with altered brain metabolism of ammonia or anatomical disturbance of the blood‐brain barrier.

Shirish Paranjpe, William C. Bowen, Aaron W. Bell, Kari Nejak‐Bowen, Jian‐Hua Luo, George K. Michalopoulos – 29 May 2007 – Hepatocyte growth factor (HGF) and its receptor c‐Met are involved in liver regeneration. The role of HGF and c‐Met in liver regeneration in rat following two‐thirds partial hepatectomy (PHx) was investigated using RNA interference to silence HGF and c‐Met in separate experiments. A mixture of 2 c‐Met‐specific short hairpin RNA (ShRNA) sequences, ShM1 and ShM2, and 3 HGF‐specific ShRNA, ShH1, ShH3, and ShH4, were complexed with linear polyethylenimine.

Alexandre Louvet, Sylvie Naveau, Marcelle Abdelnour, Marie‐José Ramond, Emmanuel Diaz, Laetitia Fartoux, Sébastien Dharancy, Frédéric Texier, Antoine Hollebecque, Lawrence Serfaty, Emmanuel Boleslawski, Pierre Deltenre, Valérie Canva, François‐René Pruvot, Philippe Mathurin – 29 May 2007 – Early identification of patients with severe (discriminant function ≥ 32) alcoholic hepatitis (AH) not responding to corticosteroids is crucial. We generated a specific prognostic model (Lille model) to identify candidates early on for alternative therapies.

Akira Hirose, Masafumi Ono, Toshiji Saibara, Yasuko Nozaki, Kosei Masuda, Akemi Yoshioka, Masaya Takahashi, Naoaki Akisawa, Shinji Iwasaki, Jude A. Oben, Saburo Onishi – 29 May 2007 – Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma. At present there is no effective and accepted therapy for NASH.