Prediction of long‐term morbidity and mortality after liver transplantation using two‐dimensional shear wave elastography compared with liver biopsy

Mohammad Amin Fallahzadeh, Sumeet K. Asrani, Elham Vahhab, Vivian S. Ebrahim, Giovanna Saracino, Saleh Elwir, James F. Trotter – 6 March 2022 – The role of noninvasive liver disease assessment by two‐dimensional shear wave elastography (2D‐SWE) to diagnose fibrosis is well described in patients with chronic liver disease. However, its role in prognosis, especially after liver transplantation (LT) has not been adequately examined.

Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation

Romain Barnault, Claire Verzeroli, Carole Fournier, Maud Michelet, Anna Rita Redavid, Ievgeniia Chicherova, Marie‐Laure Plissonnier, Annie Adrait, Olga Khomich, Fleur Chapus, Mathieu Richaud, Maëva Hervieu, Veronika Reiterer, Federica Grazia Centonze, Julie Lucifora, Birke Bartosch, Michel Rivoire, Hesso Farhan, Yohann Couté, Valbona Mirakaj, Thomas Decaens, Patrick Mehlen, Benjamin Gibert, Fabien Zoulim, Romain Parent – 6 March 2022

Coagulopathy and hemostasis management in patients undergoing liver transplantation: Defining a dynamic spectrum across phases of care

Anjana A. Pillai, Michael Kriss, David P. Al‐Adra, Ryan M. Chadha, Melissa M. Cushing, Khashayar Farsad, Brett E. Fortune, Aaron S. Hess, Robert Lewandowski, Mitra K. Nadim, Trevor Nydam, Pratima Sharma, Constantine J. Karvellas, Nicolas Intagliata – 6 March 2022 – Patients with acute and chronic liver disease present with a wide range of disease states and severity that may require liver transplantation (LT). Physiologic alterations occur that are dynamic throughout all phases of perioperative care, creating complex management scenarios that necessitate multidisciplinary clinical care.

Emerging immunotherapy for HCC: A guide for hepatologists

Friedrich Foerster, Simon Johannes Gairing, Sumera Irie Ilyas, Peter Robert Galle – 6 March 2022 – HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐related death globally. HCC comprises nearly 90% of all cases of primary liver cancer. Approximately half of all patients with HCC receive systemic therapy during their disease course, particularly in the advanced stages of disease.

Sinusoidal obstruction syndrome after liver transplantation: A multicenter observational study

Aránzazu Caballero‐Marcos, Isabel Peligros, Judith Pérez‐Rojas, Isabel Campos‐Varela, Jordi Colmenero, Miguel Ángel Gómez‐Bravo, Iago Justo, Alejandra Otero, Esther Molina‐Pérez, Luisa González‐Diéguez, Carme Baliellas, Mario Romero‐Cristobal, Victoria Aguilera, Lluís Castells, Alba Díaz, Luis Miguel Marín‐Gómez, Carmelo Loinaz, Rafael Bañares, Magdalena Salcedo – 6 March 2022

Incidence of acute rejection and patient survival in combined heart–liver transplantation

Kai Zhao, Roy Wang, Malek Kamoun, Lauren Callans, Remy Bremner, Eduardo Rame, Rhondalyn McLean, Marisa Cevasco, Kim M. Olthoff, Matthew H. Levine, Abraham Shaked, Peter L. Abt – 4 March 2022 – Combined heart–liver transplantation (CHLT) is indicated for patients with concomitant end‐stage heart and liver disease or patients with amyloid heart disease where liver transplantation mitigates progression. Limited data suggest that the liver allograft provides immunoprotection for heart and kidney allografts in combined transplantation from the same donor.

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