Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease

Kangning Yao, Elena Tarabra, Daniela Sia, Raffaella Morotti, Rima Fawaz, Pamela Valentino, Nicola Santoro, Sonia Caprio, Silvia Liu, Dean Yimlamai – 20 March 2022 – Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in children. The mechanisms that drive NAFLD disease progression in this specific patient population remain poorly defined. In this study, we obtained liver biopsy samples from a multiethnic cohort of pediatric patients with NAFLD (n = 52, mean age = 13.6 years) and healthy liver controls (n = 5).

Optimized cutoffs of gamma‐glutamyl transpeptidase‐to‐platelet ratio, aspartate aminotransferase‐to‐platelet ratio index, and fibrosis‐4 scoring systems for exclusion of cirrhosis in patients with chronic hepatitis B

Xiaoqing Liu, Hu Li, Li Wei, Qiao Tang, Peng Hu – 20 March 2022 – Accurate prediction of the extent of fibrosis is of great clinical importance in patients infected with chronic hepatitis B (CHB). This study aimed to compare the performance of gamma‐glutamyl transpeptidase‐to‐platelet ratio (GPR), aspartate aminotransferase‐to‐platelet ratio index (APRI), and fibrosis‐4 (FIB‐4) in evaluating liver fibrosis stages and to identify optimized cutoffs to exclude cirrhosis.

Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity

Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Cheuk‐Ting Law, Jacinth Wing‐Sum Cheu, Derek Lee, Aki Pui‐Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po‐Yee Wong, Chun‐Ming Wong, Pek‐Lan Khong, Irene Oi‐Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung‐Cheung Yau, Carmen Chak‐Lui Wong – 17 March 2022

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