Efficient silencing of hepatitis B virus S gene through CRISPR‐mediated base editing

Hao Zhou, Xiaomei Wang, Clifford J. Steer, Guisheng Song, Junqi Niu – 25 March 2022 – Hepatitis B virus (HBV) infection is a major risk factor of liver cirrhosis and hepatocellular carcinoma. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) has been used to precisely edit the HBV genome and eliminate HBV through non‐homologous end‐joining repair of double‐stranded break (DSB). However, the CRISPR/Cas9‐mediated DSB triggers instability of host genome and exhibits low efficiency to edit genome, limiting its application.

Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score

Rish K. Pai, Vipul Jairath, Malcolm Hogan, Guangyong Zou, Oyedele A. Adeyi, Quentin M. Anstee, Bashar A. Aqel, Cynthia Behling, Elizabeth J. Carey, Andrew D. Clouston, Kathleen Corey, Brian G. Feagan, David E. Kleiner, Christopher Ma, Stefanie C. McFarlane, Mazen Noureddin, Vlad Ratziu, Mark A. Valasek, Zobair M. Younossi, Stephen A. Harrison, Rohit Loomba – 24 March 2022

Cirrhotic cardiomyopathy: Appraisal of the original and revised criteria in predicting posttransplant cardiac outcomes

Ashley Spann, Christopher Coe, Teminioluwa Ajayi, Garren Montgomery, Mohammed Shwetar, Adesola Oje, Jeffrey Annis, James C. Slaughter, Sophoclis Alexopoulos, Evan Brittain, Manhal Izzy – 24 March 2022 – Cardiovascular disease (CVD) significantly contributes to morbidity and mortality after liver transplantation (LT). Cirrhotic cardiomyopathy (CCM) is a risk factor for CVD after transplant. CCM criteria were originally introduced in 2005 with a revision proposed in 2020 reflecting echocardiographic technology advancements.

Risk of liver‐related events by age and diabetes duration in patients with diabetes and nonalcoholic fatty liver disease

Xinrong Zhang, Grace Lai‐Hung Wong, Terry Cheuk‐Fung Yip, Johnny T. K. Cheung, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Huapeng Lin, Jimmy Che‐To Lai, Henry Lik‐Yuen Chan, Alice Pik‐Shan Kong, Vincent Wai‐Sun Wong – 24 March 2022

Donation after circulatory death transplant outcomes using livers recovered by local surgeons

Caroline C. Jadlowiec, Elizabeth Macdonough, Kylie Pont, Kristi Valenti, Blanca Lizaola‐Mayo, Abigail Brooks, Devika Das, Raymond Heilman, Amit K. Mathur, Winston Hewitt, Adyr Moss, Bashar Aqel, Kunam S. Reddy – 24 March 2022 – Donation after circulatory death (DCD) liver transplantation (LT) outcomes have been attributed to multiple variables, including procurement surgeon recovery techniques.

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