Identification of hepatic steatosis in living liver donors by machine learning models

Jihye Lim, Seungbong Han, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Dong Hwan Jung, Sung‐Gyu Lee, Ki‐Hun Kim, Jonggi Choi – 3 April 2022 – Selecting an optimal donor for living donor liver transplantation is crucial for the safety of both the donor and recipient, and hepatic steatosis is an important consideration. We aimed to build a prediction model with noninvasive variables to evaluate macrovesicular steatosis in potential donors by using various prediction models.

HBsAg isoform dynamics during NAP‐based therapy of HBeAg‐negative chronic HBV and HBV/HDV infection

Michel Bazinet, Mark Anderson, Victor Pântea, Gheorghe Placinta, Iurie Moscalu, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Liviu Iarovoi, Valentina Smesnoi, Tatina Musteata, Alina Jucov, Ulf Dittmer, Jeff Gersch, Vera Holzmayer, Mary Kuhns, Gavin Cloherty, Andrew Vaillant – 1 April 2022 – Nucleic acid polymers block the assembly of hepatitis B virus (HBV) subviral particles, effectively preventing hepatitis B surface antigen (HBsAg) replenishment in the circulation.

Intestinal virome in patients with alcohol use disorder and after abstinence

Cynthia L. Hsu, Xinlian Zhang, Lu Jiang, Sonja Lang, Phillipp Hartmann, David Pride, Derrick E. Fouts, Peter Stärkel, Bernd Schnabl – 1 April 2022 – Alcohol use is a leading cause of chronic liver disease worldwide, and changes in the microbiome associated with alcohol use contribute to patients’ risk for liver disease progression. Less is known about the effects of alcohol use on the intestinal viral microbiome (virome) and interactions between bacteriophages and their target bacteria.

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Jennifer R. Kramer, Yamini Natarajan, Jianliang Dai, Xian Yu, Liang Li, Hashem B. El‐Serag, Fasiha Kanwal – 1 April 2022

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