Predicting NAFLD prevalence in the United States using National Health and Nutrition Examination Survey 2017–2018 transient elastography data and application of machine learning

Mazen Noureddin, Fady Ntanios, Deepa Malhotra, Katherine Hoover, Birol Emir, Euan McLeod, Naim Alkhouri – 31 March 2022 – This cohort analysis investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD with fibrosis at different stages, associated clinical characteristics, and comorbidities in the general United States population and a subpopulation with type 2 diabetes mellitus (T2DM), using the National Health and Nutrition Examination Survey (NHANES) database (2017–2018).

Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway

Palak Ahuja, Xinyi Bi, Chun Fai Ng, Margaret Chui Ling Tse, Miaojia Hang, Brian Pak Shing Pang, Elsie Chit Yu Iu, Wing Suen Chan, Xin Ci Ooi, Anqi Sun, Oana Herlea‐Pana, Zhixue Liu, Xiuying Yang, Baowei Jiao, Xin Ma, Kelvin Ka Lok Wu, Leo Tsz On Lee, Kenneth King Yip Cheng, Chi Wai Lee, Chi Bun Chan – 31 March 2022

LKB1 acts as a critical brake for the glucagon‐mediated fasting response

Suehelay Acevedo‐Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat‐Shliom – 30 March 2022 – As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, with glucagon being a key initiator of the hepatic fasting response. However, the precise mechanisms controlling fasting are not well defined.

Analysis of direct‐acting antiviral‐resistant hepatitis C virus haplotype diversity by single‐molecule and long‐read sequencing

Kozue Yamauchi, Mitsuaki Sato, Leona Osawa, Shuya Matsuda, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Ryo Katoh, Masaru Muraoka, Yuichiro Suzuki, Akihisa Tatsumi, Mika Miura, Shinichi Takano, Fumitake Amemiya, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Shinya Maekawa, Nobuyuki Enomoto – 30 March 2022 – The method of analyzing individual resistant hepatitis C virus (HCV) by a combination of haplotyping and resistance‐associated substitution (RAS) has not been fully elucidated because conventional sequencing has only yielded short and fragmented viral ge

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