Analysis of direct‐acting antiviral‐resistant hepatitis C virus haplotype diversity by single‐molecule and long‐read sequencing

Kozue Yamauchi, Mitsuaki Sato, Leona Osawa, Shuya Matsuda, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Ryo Katoh, Masaru Muraoka, Yuichiro Suzuki, Akihisa Tatsumi, Mika Miura, Shinichi Takano, Fumitake Amemiya, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Shinya Maekawa, Nobuyuki Enomoto – 30 March 2022 – The method of analyzing individual resistant hepatitis C virus (HCV) by a combination of haplotyping and resistance‐associated substitution (RAS) has not been fully elucidated because conventional sequencing has only yielded short and fragmented viral ge

LKB1 acts as a critical brake for the glucagon‐mediated fasting response

Suehelay Acevedo‐Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat‐Shliom – 30 March 2022 – As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, with glucagon being a key initiator of the hepatic fasting response. However, the precise mechanisms controlling fasting are not well defined.

A look into hemostatic characteristics during pediatric liver transplantation using the thromboelastometry (ROTEM®) test

Jun‐Ki Cho, Young‐Jin Moon, In‐Kyung Song, En‐Joo Kang, Won‐Jung Shin, Gyu‐Sam Hwang – 29 March 2022 – There is a paucity of evidence about the coagulation profile regarding the complexity of children undergoing liver transplantation (LT). This study aimed to investigate intraoperative hemostatic changes during pediatric LT according to the etiology for LT and examine the ability of rotational thromboelastometry (ROTEM®, TEM International GmbH, Munich, Germany) as a point‐of‐care monitoring method.

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