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Vladimir V. Loukachov, Karel A. Dort, Robin Erken, Henk W. Reesink, Neeltje A. Kootstra – 22 March 2022

Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver

Joshua K. Morrison, Charles DeRossi, Isaac L. Alter, Shikha Nayar, Mamta Giri, Chi Zhang, Judy H. Cho, Jaime Chu – 21 March 2022 – The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single‐cell transcriptome of the adult zebrafish liver to determine its utility as a model for studying liver fibrosis.

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