Insights from shotgun metagenomics into bacterial species and metabolic pathways associated with NAFLD in obese youth

Todd Testerman, Zhongyao Li, Brittany Galuppo, Joerg Graf, Nicola Santoro – 27 March 2022 – Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease and is often the precursor for more serious liver conditions such as nonalcoholic steatohepatitis and cirrhosis. Although the gut microbiome has been implicated in the development of NAFLD, the strong association of obesity with NAFLD and its effect on microbiome structure has made interpreting study outcomes difficult.

Mac‐2‐binding protein glycan isomer predicts all malignancies after sustained virological response in chronic hepatitis C

Kazuhito Kawata, Masanori Atsukawa, Kazuyoshi Ohta, Takeshi Chida, Hidenao Noritake, Taeang Arai, Katsuhiko Iwakiri, Satoshi Yasuda, Hidenori Toyoda, Tomomi Okubo, Atsushi Hiraoka, Tsunamasa Watanabe, Haruki Uojima, Akito Nozaki, Joji Tani, Asahiro Morishita, Fujito Kageyama, Yuzo Sasada, Masamichi Nagasawa, Masahiro Matsushita, Tatsuki Oyaizu, Shigeru Mikami, Tadashi Ikegami, Hiroshi Abe, Kentaro Matsuura, Yasuhito Tanaka, Akihito Tsubota – 27 March 2022 – Despite reports of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection after achieving sustained

RNA sequencing analysis of hepatocellular carcinoma identified oxidative phosphorylation as a major pathologic feature

Yongjun Liu, David P. Al‐Adra, Ruoxin Lan, Geunyoung Jung, Huihua Li, Matthew M. Yeh, Yao‐Zhong Liu – 27 March 2022 – Dysregulation of expression of functional genes and pathways plays critical roles in the etiology and progression of hepatocellular carcinoma (HCC). Next generation‐based RNA sequencing (RNA‐seq) offers unparalleled power to comprehensively characterize HCC at the whole transcriptome level. In this study, 17 fresh‐frozen HCC samples with paired non‐neoplastic liver tissue from Caucasian patients undergoing liver resection or transplantation were used for RNA‐seq analysis.

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou – 27 March 2022

Subscribe to