A look into hemostatic characteristics during pediatric liver transplantation using the thromboelastometry (ROTEM®) test

Jun‐Ki Cho, Young‐Jin Moon, In‐Kyung Song, En‐Joo Kang, Won‐Jung Shin, Gyu‐Sam Hwang – 29 March 2022 – There is a paucity of evidence about the coagulation profile regarding the complexity of children undergoing liver transplantation (LT). This study aimed to investigate intraoperative hemostatic changes during pediatric LT according to the etiology for LT and examine the ability of rotational thromboelastometry (ROTEM®, TEM International GmbH, Munich, Germany) as a point‐of‐care monitoring method.

Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

Sung Hwan Lee, Sun Young Yim, Yun Seong Jeong, Qi‐Xiang Li, Sang‐Hee Kang, Bo Hwa Sohn, Shwetha V. Kumar, Ji‐Hyun Shin, You Rhee Choi, Jae‐Jun Shim, Hayeon Kim, Ji Hoon Kim, Shin Kim, Sheng Guo, Randy L. Johnson, Ahmed Kaseb, Koo Jeong Kang, Yun Shin Chun, Hee Jin Jang, Byoung Gill Lee, Hyun Goo Woo, Min Jin Ha, Rehan Akbani, Lewis R. Roberts, David A. Wheeler, Ju‐Seog Lee – 28 March 2022

Circulating HBV RNA: From biology to clinical applications

Rui Deng, Shi Liu, Sheng Shen, Haitao Guo, Jian Sun – 27 March 2022 – Chronic HBV infection can hardly be cured due to the persistence of an intrahepatic pool of viral covalently closed circular DNA (cccDNA) transcription template, which is refractory to current antivirals. The direct analyses of cccDNA quantity and transcriptional activity require an invasive biopsy. Recently, circulating HBV RNA has been identified as a promising noninvasive surrogate marker of cccDNA and can be used for monitoring disease progression and predicting prognosis of patients with chronic HBV infection.

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