Ablation of high‐mobility group box‐1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling‐deficient mice

Dipti Athavale, Zhuolun Song, Romain Desert, Hui Han, Sukanta Das, Xiaodong Ge, Sai Santosh Babu Komakula, Wei Chen, Shenglan Gao, Daniel Lantvit, Grace Guzman, Natalia Nieto – 27 March 2022 – Silencing the Hippo kinases mammalian sterile 20‐like 1 and 2 (MST1/2) activates the transcriptional coactivator yes‐associated protein (YAP) in human hepatocellular carcinoma (HCC). Hepatocyte‐derived high‐mobility group box‐1 (HMGB1) regulates YAP expression; however, its contribution to HCC in the context of deregulated Hippo signaling is unknown.

Circulating HBV RNA: From biology to clinical applications

Rui Deng, Shi Liu, Sheng Shen, Haitao Guo, Jian Sun – 27 March 2022 – Chronic HBV infection can hardly be cured due to the persistence of an intrahepatic pool of viral covalently closed circular DNA (cccDNA) transcription template, which is refractory to current antivirals. The direct analyses of cccDNA quantity and transcriptional activity require an invasive biopsy. Recently, circulating HBV RNA has been identified as a promising noninvasive surrogate marker of cccDNA and can be used for monitoring disease progression and predicting prognosis of patients with chronic HBV infection.

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