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Jennifer R. Kramer, Yamini Natarajan, Jianliang Dai, Xian Yu, Liang Li, Hashem B. El‐Serag, Fasiha Kanwal – 1 April 2022

Intestinal virome in patients with alcohol use disorder and after abstinence

Cynthia L. Hsu, Xinlian Zhang, Lu Jiang, Sonja Lang, Phillipp Hartmann, David Pride, Derrick E. Fouts, Peter Stärkel, Bernd Schnabl – 1 April 2022 – Alcohol use is a leading cause of chronic liver disease worldwide, and changes in the microbiome associated with alcohol use contribute to patients’ risk for liver disease progression. Less is known about the effects of alcohol use on the intestinal viral microbiome (virome) and interactions between bacteriophages and their target bacteria.

HBsAg isoform dynamics during NAP‐based therapy of HBeAg‐negative chronic HBV and HBV/HDV infection

Michel Bazinet, Mark Anderson, Victor Pântea, Gheorghe Placinta, Iurie Moscalu, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Liviu Iarovoi, Valentina Smesnoi, Tatina Musteata, Alina Jucov, Ulf Dittmer, Jeff Gersch, Vera Holzmayer, Mary Kuhns, Gavin Cloherty, Andrew Vaillant – 1 April 2022 – Nucleic acid polymers block the assembly of hepatitis B virus (HBV) subviral particles, effectively preventing hepatitis B surface antigen (HBsAg) replenishment in the circulation.

Predicting NAFLD prevalence in the United States using National Health and Nutrition Examination Survey 2017–2018 transient elastography data and application of machine learning

Mazen Noureddin, Fady Ntanios, Deepa Malhotra, Katherine Hoover, Birol Emir, Euan McLeod, Naim Alkhouri – 31 March 2022 – This cohort analysis investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD with fibrosis at different stages, associated clinical characteristics, and comorbidities in the general United States population and a subpopulation with type 2 diabetes mellitus (T2DM), using the National Health and Nutrition Examination Survey (NHANES) database (2017–2018).

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