C‐C motif chemokine ligand 5 confines liver regeneration by down‐regulating reparative macrophage‐derived hepatocyte growth factor in a forkhead box O 3a–dependent manner

Miao Huang, Junzhe Jiao, Hao Cai, Yichi Zhang, Yuhan Xia, Jiacheng Lin, Zhi Shang, Yihan Qian, Fang Wang, Hailong Wu, Xiaoni Kong, Jinyang Gu – 14 March 2022

Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

Theresia M. Schnurr, Sophia Figueroa Katz, Johanne M. Justesen, Jack W. O’Sullivan, Peter Saliba‐Gustafsson, Themistocles L. Assimes, Ivan Carcamo‐Orive, Aijaz Ahmed, Euan A. Ashley, Torben Hansen, Joshua W. Knowles – 14 March 2022 – Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity.

Long‐term follow‐up of living liver donors: A single‐center experience

Ehab E. Abdel‐Khalek, Mohamed Abdel‐Wahab, Mohamed H. Elgazzar, Mahmoud A. Khattab, Abdel‐Hady El‐Gilany, Hesham M. Elgouhari, Ahmed Shehta – 14 March 2022 – Living donors are healthy individuals who are exposed to a major surgical procedure during which a major part of their liver is resected. Data on the long‐term consequences of living liver donation are scarce. This study examined clinical, laboratory, and long‐term health‐related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48–168 months of postdonation follow‐up.

The fundamentals of sex‐based disparity in liver transplantation: Understanding can lead to change

Noreen Singh, Kymberly D. Watt, Rahima A. Bhanji – 14 March 2022 – Liver transplantation (LT) is the definitive treatment for end‐stage liver disease. Unfortunately, women are disadvantaged at every stage of the LT process. We conducted a literature review to increase the understanding of this disparity. Hormonal differences, psychological factors, and Model for End‐Stage Liver Disease (MELD) score inequalities are some pretransplantation factors that contribute to this disparity.

Transmembrane channel activity in human hepatocytes and cholangiocytes derived from induced pluripotent stem cells

Rodrigo M. Florentino, Qin Li, Michael C. Coard, Nils Haep, Takashi Motomura, Ricardo Diaz‐Aragon, Lanuza A. P. Faccioli, Sriram Amirneni, Zehra N. Kocas‐Kilicarslan, Alina Ostrowska, James E. Squires, Andrew P. Feranchak, Alejandro Soto‐Gutierrez – 14 March 2022 – The initial creation of human‐induced pluripotent stem cells (iPSCs) set the foundation for the future of regenerative medicine. Human iPSCs can be differentiated into a variety of cell types in order to study normal and pathological molecular mechanisms.

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