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Vladimir V. Loukachov, Karel A. Dort, Robin Erken, Henk W. Reesink, Neeltje A. Kootstra – 22 March 2022
Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver
Joshua K. Morrison, Charles DeRossi, Isaac L. Alter, Shikha Nayar, Mamta Giri, Chi Zhang, Judy H. Cho, Jaime Chu – 21 March 2022 – The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single‐cell transcriptome of the adult zebrafish liver to determine its utility as a model for studying liver fibrosis.
Acute cellular rejection in liver transplantation recipients following coronavirus disease 2019 vaccination
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit – 20 March 2022
Hepatic kinome atlas: An in‐depth identification of kinase pathways in liver fibrosis of humans and rodents
Justin F. Creeden, Zachary A. Kipp, Mei Xu, Robert M. Flight, Hunter N. B. Moseley, Genesee J. Martinez, Wang‐Hsin Lee, Khaled Alganem, Ali S. Imami, Megan R. McMullen, Sanjoy Roychowdhury, Atta M. Nawabi, Jennifer A. Hipp, Samir Softic, Steven A. Weinman, Robert McCullumsmith, Laura E. Nagy, Terry D. Hinds – 20 March 2022
Association between social determinants of health and rates of liver transplantation in individuals with cirrhosis
Jennifer A. Flemming, Hala Muaddi, Maja Djerboua, Paula Neves, Gonzalo Sapisochin, Nazia Selzner – 20 March 2022
A pan‐genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes – 20 March 2022
Donor–recipient human leukocyte antigen A mismatching is associated with hepatic artery thrombosis, sepsis, graft loss, and reduced survival after liver transplant
Christopher Bricogne, Neil Halliday, Raymond Fernando, Emmanuel A. Tsochatzis, Brian R. Davidson, Mark Harber, Rachel H. Westbrook – 20 March 2022 – Human leukocyte antigen (HLA) matching is not routinely performed for liver transplantation as there is no consistent evidence of benefit; however, the impact of HLA mismatching remains uncertain. We explored the effect of class I and II HLA mismatching on graft failure and mortality. A total of 1042 liver transplants performed at a single center between 1999 and 2016 with available HLA typing data were included.
Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease
Kangning Yao, Elena Tarabra, Daniela Sia, Raffaella Morotti, Rima Fawaz, Pamela Valentino, Nicola Santoro, Sonia Caprio, Silvia Liu, Dean Yimlamai – 20 March 2022 – Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in children. The mechanisms that drive NAFLD disease progression in this specific patient population remain poorly defined. In this study, we obtained liver biopsy samples from a multiethnic cohort of pediatric patients with NAFLD (n = 52, mean age = 13.6 years) and healthy liver controls (n = 5).
Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury
Li Chen, Jun Dong, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu, Chaojun Yan, Yong Chen, He He, Qingtao Meng, Zhiyin Song – 20 March 2022
Optimized cutoffs of gamma‐glutamyl transpeptidase‐to‐platelet ratio, aspartate aminotransferase‐to‐platelet ratio index, and fibrosis‐4 scoring systems for exclusion of cirrhosis in patients with chronic hepatitis B
Xiaoqing Liu, Hu Li, Li Wei, Qiao Tang, Peng Hu – 20 March 2022 – Accurate prediction of the extent of fibrosis is of great clinical importance in patients infected with chronic hepatitis B (CHB). This study aimed to compare the performance of gamma‐glutamyl transpeptidase‐to‐platelet ratio (GPR), aspartate aminotransferase‐to‐platelet ratio index (APRI), and fibrosis‐4 (FIB‐4) in evaluating liver fibrosis stages and to identify optimized cutoffs to exclude cirrhosis.