Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen – 15 June 2022

Patient‐centered care: Key elements applicable to chronic liver disease

Manisha Verma, Mayur Brahmania, Brett E. Fortune, Sumeet K. Asrani, Michael Fuchs, Michael L. Volk – 15 June 2022 – Chronic liver disease (CLD) is a progressive illness with high symptom burden and functional and cognitive impairment, often with comorbid mental and substance use disorders. These factors lead to significant deterioration in quality of life, with immense burden on patients, caregivers, and healthcare.

Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation

Hedayatullah Esmati, Marieke Rosmalen, Patrick F. Rheenen, Marieke T. Boer, Aad P. Berg, Hubert P. J. Doef, Michel Rayar, Ruben H.J. Kleine, Robert J. Porte, Vincent E. Meijer, Henkjan J. Verkade – 13 June 2022 – Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).

Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B

Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi, Juanjuan Chen, Yuning Wei, Yanfang Pan, Huaixin Dang, Xiong Wei, Ashraf Siddig Yousif, Jeysen Yogaratnam, Qiong Zhou, Henri Lichenstein, Tian Xu – 13 June 2022

Iron overload disorders

Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley – 13 June 2022 – Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver enzymes. Confirmatory homeostatic iron regulator (HFE) genetic testing for C282Y and H63D, mutations most encountered in hereditary hemochromatosis, should be pursued in evaluation of hyperferritinemia.

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