Christopher A. Dietz, Markus Cornberg – 28 February 2022

Samar H. Ibrahim, Binita M. Kamath, Kathleen M. Loomes, Saul J. Karpen – 28 February 2022 – With the application of modern investigative technologies, cholestatic liver diseases of genetic etiology are increasingly identified as the root cause of previously designated “idiopathic” adult and pediatric liver diseases. Here, we review advances in the field enhanced by a deeper understanding of the phenotypes associated with specific gene defects that lead to cholestatic liver diseases.

Chenhua Wang, Ludi Zhang, Zhen Sun, Xiang Yuan, Baihua Wu, Jin Cen, Lei Cui, Kun Zhang, Chun Li, Jingqi Wu, Yajing Shu, Wenbin Sun, Jing Wang, Lijian Hui – 28 February 2022

Sapna Humar, Judy Jung, Sandra Krause, Nazia Selzner, Susan Abbey – 28 February 2022 – Anonymous living organ donation has recently become more common in select transplantation programs, with donors voluntarily offering a kidney or a lobe of their liver to those in need. These anonymous donations may be directed to a specific recipient or nondirected, and anonymity may be one way or reciprocal. Given their unique situation, we interviewed a cohort of anonymous living liver donors and explored their opinions surrounding anonymity and its implications in living liver donation.

Maria Stepanova, Khaled Kabbara, Denise Mohess, Manisha Verma, Alva Roche‐Green, Saleh AlQahtani, Janus Ong, Patrizia Burra, Zobair M. Younossi – 27 February 2022 – As the US population ages, more elderly patients may need liver transplantation. Our aim was to assess recent trends among elderly individuals requiring liver transplant in the United States. Scientific Registry of Transplant Recipients data (2002–2020) were used to select elderly (≥65 years) liver transplant candidates and assess on‐list and posttransplant outcomes.

Meng‐Ju Wu, Lei Shi, Joshua Merritt, Andrew X. Zhu, Nabeel Bardeesy – 27 February 2022 – Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most frequently mutated metabolic genes across human cancers. These hotspot gain‐of‐function mutations cause the IDH enzyme to aberrantly generate high levels of the oncometabolite, R‐2‐hydroxyglutarate, which competitively inhibits enzymes that regulate epigenetics, DNA repair, metabolism, and other processes. Among epithelial malignancies, IDH mutations are particularly common in intrahepatic cholangiocarcinoma (iCCA).

Jordyn Silverstein, Francis Y. Yao, Joshua D. Grab, Hillary J. Braun, John Roberts, Jennifer L. Dodge, Neil Mehta – 27 February 2022 – Living donor liver transplantation (LDLT) is an attractive option to decrease waitlist dropout, particularly for patients with hepatocellular carcinoma (HCC) who face lengthening waiting times. Using the United Network for Organ Sharing (UNOS) national database, trends in LDLT utilization for patients with HCC were evaluated, and post‐LT outcomes for LDLT versus deceased donor liver transplantation (DDLT) were compared.

Antonella Putignano, Thierry Gustot – 27 February 2022

Ajay Kumar Patwa, Sumit Rungta, Vivek Kumar – 27 February 2022

Lydia Sastre, Raquel García, Clara Viñals, Antonio J. Amor, Gema Yago, Alicia Hervás, Lorena Sánchez, Joan Trabal, Judit Molero, Laia Escudé, Giulia Pagano, Miquel Blasco, Rosa Gilabert, Pablo Ruiz, Jordi Colmenero, Miquel Navasa, Emilio Ortega, Gonzalo Crespo – 27 February 2022 – Although liver transplantation (LT) recipients are at high cardiovascular risk (CVR), the management of CVR factors (CVRF) after LT is far from optimal and needs to be improved.