Long‐term outcomes of crossmatch positive simultaneous liver–kidney transplantations in the United States

Samy Riad, Elizabeth S. Aby, Phuoc Le Nguyen, Scott Jackson, Nicholas Lim, John Lake – 17 February 2022 – The long‐term outcomes of positive crossmatch (+XM) simultaneous liver–kidney (SLK) transplantations are conflicting. We examined the association between crossmatch status and SLK outcomes in recipients discharged on tacrolimus and mycophenolate with or without steroids. We analyzed the Scientific Registry of Transplant Recipients for all primary SLK recipients between 2003 and 2020 with available crossmatch and induction data.

Liver zonation, revisited

Jasmin Paris, Neil C. Henderson – 16 February 2022 – The concept of hepatocyte functional zonation is well established, with differences in metabolism and xenobiotic processing determined by multiple factors including oxygen and nutrient levels across the hepatic lobule. However, recent advances in single‐cell genomics technologies, including single‐cell and nuclei RNA sequencing, and the rapidly evolving fields of spatial transcriptomic and proteomic profiling have greatly increased our understanding of liver zonation.

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